معرفی
Choel Kim, Ph.D., M.S., is an Associate Professor in the Department of Pharmacology and Chemical Biology at Baylor College of Medicine (BCM), and a member of the Dan L Duncan Comprehensive Cancer Center. He holds a Ph.D. in Biology and an M.S. in Chemistry from the University of California, San Diego (UCSD), with postdoctoral training in structural biology. His research focuses on molecular mechanisms of cGMP-dependent protein kinases (PKG), drug discovery targeting PKG isoforms, and structural biology of signaling proteins.
Kim’s lab employs techniques such as X-ray crystallography, cryo-EM, and high-throughput screening to study PKG activation, cyclic nucleotide selectivity, and their roles in diseases like aortic aneurysms and malaria. Key contributions include structural insights into PKG-cGMP interactions and the discovery of PKG inhibitors for therapeutic applications.
His grants include NIH R01 support (2015–2019) for PKG activation studies and CPRIT funding (2014–2017) for research on autophagy regulation in tumors. Kim collaborates on projects like cGMP signaling in cardiovascular biology and epigenetic drug development, leveraging structural biology to design novel therapeutics.
Publications span structural biology, drug design, and disease mechanisms, with recent work on PKG isoform-specific inhibitors and cGMP signaling in cardiomyocytes. His work bridges basic research and translational medicine, advancing understanding of kinase regulation and its clinical implications.
