Chiara Bonini

Chiara Bonini is a Full Professor at Vita-Salute San Raffaele University in the Faculty of Medicine and Surgery, with a focus on Blood Diseases (MEDS-09/B). She serves as Deputy Director of the Division of Immunology, Transplantation and Infectious Diseases Research at San Raffaele Hospital Scientific Institute, Milan, and leads the Experimental Hematology Unit there since 2008.

• 1994: MD, summa cum laude, University of Milan
• 1998: Hematology specialization, University of Pavia
• 1993: Intern, Memorial Sloan Kettering Cancer Center
• 1996-1998: Postdoctoral Fellow, Telethon Institute for Gene Therapy
• 1998-2000: Postdoctoral Fellow, Fred Hutchinson Cancer Research Center

Her research centers on immunotherapy and gene therapy for cancer, particularly genetically modified T lymphocytes to enhance safety and efficacy in allogeneic stem cell transplantation. Key contributions include the first European-approved cell and gene therapy product for oncological diseases, developed through clinical trials like "HSV-tk suicide gene transfer" and "TK007 phase I-II study".

Recent publications highlight advances in CAR T cell therapy for solid tumors, epigenetic regulation of engineered lymphocytes, and metabolic reprogramming of regulatory T cells. Her work spans hematological malignancies, autoimmune disorders, and tumor microenvironment manipulation.

• 2024-2025 articles: TGFβ inhibition, CAR T safety, autoimmune homeostasis, and metabolic T cell engineering
• 2025 courses: Hematology (6-year MD program), Blood and Immune System Diseases

Notable awards include the Van Bekkum Award, Van Rood Award, and Basic Science Award from EBMT, alongside editorial roles in journals like Molecular Therapy and Human Gene Therapy. She actively reviews grants for organizations including the European Research Council and Cancer Research UK.