Charles France

Dr. Charles France is a Professor at the University of Texas Health Science Center at San Antonio, affiliated with the Graduate School of Biomedical Sciences. His research focuses on opioid pharmacology, drug interactions, and the development of countermeasures for opioid overdose. Key areas include ventilatory depression reversal via μ-opioid receptor antagonists like methocinnamox, gabapentinoid effects on opioid potency, and the behavioral pharmacology of fentanyl analogs. His work spans preclinical models in rodents and non-human primates, emphasizing translational research. Dr. France has contributed to over 50 peer-reviewed articles since 2020, addressing opioid toxicity, cannabinoid interactions, and novel treatment strategies for substance use disorders. He is actively involved in advancing academic pathways for new medications and chairs NIH-funded projects on overdose prevention.

His recent studies highlight the long-lasting antagonism of methocinnamox on opioid self-administration and its role in preventing respiratory depression. Collaborative efforts with industry partners aim to bridge discovery and clinical application. Dr. France’s research is funded by grants from the NIH and private pharmaceutical entities, focusing on neuropharmacology and drug safety.