معرفی
Charles Andrew Czeisler is the Frank Baldino, Jr., Ph.D. Professor of Sleep Medicine at Harvard Medical School, with clinical appointments at Brigham and Women's Hospital Division of Sleep and Circadian Disorders. He directs significant research initiatives including the Sleep Matters Initiative at Brigham Health and co-founded the Harvard Work Hours Health and Safety Group. His work bridges basic circadian science with clinical applications and public health policy.
Dr. Czeisler completed his A.B. magna cum laude in Biochemistry and Molecular Biology at Harvard College (1974), followed by a Ph.D. in Neuro- and Biobehavioral Sciences at Stanford University (1978) under William C. Dement, an M.D. from Stanford University School of Medicine (1981), and a Senior Fellowship in Health Policy at Harvard's Kennedy School of Government (1983).
His laboratory research focuses on the neurobiology of the human circadian pacemaker in the suprachiasmatic nucleus and its interaction with the sleep homeostat. Current investigations examine melatonin's role in sleep organization, photic resetting mechanisms through intrinsically photosensitive retinal ganglion cells containing melanopsin, and how circadian/homeostatic processes regulate sleep and neurobehavioral function. His team studies novel wake-promoting countermeasures, exercise effects on circadian rhythms, fMRI of sleep-deprived brains, aging influences on sleep, chronic sleep restriction impacts, and space flight effects on circadian rhythms.
Analysis of Dr. Czeisler's recent publications reveals a strong emphasis on translational research connecting basic circadian science with clinical applications. His work increasingly examines sleep's relationship with long COVID, mental health, occupational safety (particularly for medical residents and transportation workers), and technological approaches to sleep assessment. The research demonstrates growing interdisciplinary collaboration across sleep medicine, public health, digital health technology, and policy development.
- Aschoff's Rule International Award in Circadian Biology (2001)
- Lifetime Achievement Award, National Sleep Foundation (2008)
- Lord Adrian Gold Medal, Royal Society of Medicine (2008)
- Election to National Academy of Medicine (2010)
- NASA Johnson Space Center Director's Innovation Award (2014)
- Peter C. Farrell Prize in Sleep Medicine (2019)
- Establishment of Annual Charles A. Czeisler Lectureship, Monash University (2023)
- Sleep Hero Award (2024)
Dr. Czeisler has mentored numerous researchers who have become leaders in sleep medicine, including Robbins, Weaver, Barger, Quan, and Duffy. His research is supported by multiple active grants including a $5.8 million Department of Defense project developing a blood test to measure sleep deprivation, an international task force on sleep/circadian rhythms and youth depression funded by Wellcome Trust, and clinical trials investigating treatments for shift work disorder. His work has directly influenced policies on medical resident work hours, airline crew scheduling, and daylight saving time.
Dr. Czeisler leads the Division of Sleep and Circadian Disorders at Brigham and Women's Hospital and the Harvard Medical School Division of Sleep Medicine. Through the Sleep Matters Initiative, his team applies circadian research to night workers including medical residents and police. His laboratory collaborates with NASA on space flight circadian research and with the International Association of Circadian Health Clinics on global implementation of circadian medicine principles.
