Chaolin Zhang

Chaolin Zhang, PhD, is an Associate Professor of Systems Biology and Biochemistry and Molecular Biophysics at Columbia University's Vagelos College of Physicians and Surgeons, affiliated with the Motor Neuron Center. His research focuses on RNA regulatory networks in the nervous system, particularly how these networks define neuronal cell types and their dysregulation in neurodegenerative and neurodevelopmental diseases. He combines computational and experimental approaches to study alternative splicing, RNA-protein interactions, and their roles in health and disease.

Key research areas include the role of RNA-binding proteins in neuronal differentiation, splicing regulation in cancer, and the interplay between RNA networks and immune responses. The Zhang Lab's work bridges systems biology and molecular mechanisms, with applications to neurological disorders and oncology.

Recent publications highlight advancements in CRISPR-based screening of splicing elements, multi-omics analyses of glioblastoma, and the impact of RNA regulation on synapse properties. His lab is also engaged in developing computational tools for analyzing splicing patterns and RNA-protein interactions.

Dr. Zhang collaborates across disciplines, leveraging expertise in bioinformatics, molecular biology, and neuroscience. His work is supported by affiliations with Columbia's Foundations of Data Science and Health Analytics Committee, reflecting a commitment to interdisciplinary research.