Cecilia Leal

Cecilia Leal is a Professor and Racheff Faculty Scholar in the Department of Materials Science and Engineering at the University of Illinois at Urbana-Champaign, with additional appointments at the Carle Illinois College of Medicine, Materials Research Laboratory, and Beckman Institute. Her interdisciplinary research program bridges materials science, biophysics, and medicine to develop innovative therapeutic delivery systems.

Dr. Leal's research focuses on the self-organization of biomolecular systems, particularly lipid membranes, peptides, and nucleic acids. Her lab investigates how structural complexity of lipids and bio-membranes relates to disease mechanisms and informs the design of better gene and drug delivery systems. Key projects include developing lipid nanoparticles for mRNA delivery, studying polymer-lipid hybrid membranes, and characterizing lipid droplet dynamics in metabolic diseases. The lab employs advanced techniques including Small Angle X-ray Scattering, Cryo-EM, and live cell imaging.

Her recent publications (2023-2025) reveal a strong emphasis on lipid-based delivery systems for mRNA therapeutics and cancer treatment, with particular attention to how nanostructure affects delivery efficiency. The research spans from fundamental biophysics of lipid-polymer interactions to applied therapeutic development, demonstrating consistent translation of basic science to medical applications.

• University of Illinois Provost's Distinguished Promotion to Full Professor Award (2024)
• University of Illinois Scholar (2023)
• NIH New Innovator Award (2016)
• NSF CAREER Award (2016)
• Racheff Faculty Scholar Award (2019)

Dr. Leal has mentored numerous graduate students and postdocs, many now in prominent positions at MIT, Stanford, Dow Chemical, and pharmaceutical companies. Her research is supported by multiple NIH and NSF grants, and she maintains active collaborations with medical researchers studying obesity, cancer, and respiratory diseases. She teaches core courses including MSE 201 (Phases and Phase Relations) and MSE 473 (Biomolecular Materials Science), consistently earning excellent teaching ratings.

The Leal Lab operates as an interdisciplinary team of materials scientists, physicists, and chemists using cutting-edge characterization tools to solve biomedical challenges. The lab's work on lipid nanoparticle structure has direct relevance to next-generation mRNA vaccines and cancer therapies, with several publications highlighted in C&EN News and other prominent scientific media.