معرفی
Dr. Casey Paquola leads the Multiscale Neurodevelopment Team at the Institute of Neuroscience and Medicine (INM-7), Research Center Jülich. His research focuses on understanding neurodevelopmental processes through multiscale frameworks that integrate postmortem histology, transcriptomics, and in vivo neuroimaging (e.g., MRI, EEG). The team studies cytoarchitecture maturation, connectivity, and functional dynamics across early life to elucidate mechanisms of neurodevelopmental disorders. Their work emphasizes microstructure as a bridge between postmortem and in vivo data, identifying principles like large-scale cortical gradients.
Research methods include microscopy, neuroimaging, and computational modeling to construct brain models. Key areas of study include the default mode network, epilepsy-related brain changes, and the interplay between genetics and brain structure. The team develops tools like BrainSpace and Micapipe for analyzing structural-functional relationships in neuroimaging datasets.
- Led initiatives: ENIGMA-Toolbox for transdiagnostic analysis, BrainStat for statistical neuroimaging analysis.
- Focus areas: Cortical development gradients, functional resilience, and translational neuroimaging.
- Collaborations: Multidisciplinary teams combining computational, clinical, and experimental neuroscience.
Future work aims to advance precision medicine through personalized brain mapping and understanding neurodevelopmental disorders' multiscale origins.
