Caroline Yi-Shoo Kuo

Dr. Caroline Yi-Shoo Kuo is an Assistant Professor-in-Residence in Pediatrics at the University of California Los Angeles (UCLA) School of Medicine. She holds the Pennington Family Foundation Endowed Term Chair in Pediatrics and focuses on translational research at the intersection of gene therapy, molecular biology, and immunology.

• Current Role: Assistant Professor-in-Residence, Pediatrics, UCLA
• Key Research Areas: Gene therapy for primary immunodeficiencies, genome editing, hematopoietic stem cell engineering, and clinical translation of genetic therapies.

Dr. Kuo’s research interests center on developing gene therapy approaches for monogenic immune disorders, including X-linked agammaglobulinemia (XLA), severe combined immunodeficiency (SCID), and related conditions. Her work emphasizes optimizing viral vectors, DNA repair pathways, and clinical trial design for these therapies.

Publication Trends over the past decade highlight her leadership in clinical gene therapy for conditions like LAD-I, XLA, and ADA-SCID. She explores the interplay between immunology and molecular engineering, with recent studies on DNA contamination effects on stem cell function and genome editing for inborn immunity errors.