معرفی
Carl Ernst, PhD is a Professor in the Department of Human Genetics at McGill University's Faculty of Medicine, where he heads the Rare Neurodevelopmental Disorders Laboratory (RNDL) at The Neuro (Montreal Neurological Institute-Hospital). His research integrates stem cell biology and genetic engineering to model rare neurological diseases, with focus on cellular phenotyping and therapeutic development.
His research program centers on neurodevelopmental disorders using human stem cell models to investigate epigenetic regulation, neural differentiation, and cellular metabolism. Key areas include Kabuki syndrome, FOXG1-related disorders, ACTL6B mutations, and GRIN2B dysfunction, with emphasis on identifying molecular convergence points across diverse neurodevelopmental conditions. The RNDL laboratory employs advanced techniques in cellular engineering to advance therapeutic candidates toward clinical trials.
Ernst's publication portfolio demonstrates consistent focus on molecular mechanisms underlying rare neurodevelopmental conditions, with recurring themes of epigenetic dysregulation, neural progenitor dynamics, and cellular metabolism defects. His work bridges basic stem cell research with translational applications, particularly in developing cellular models for drug screening.
Scientific recognition includes:
- Graduate Teaching Award of Excellence (Department of Human Genetics)
- Canada Research Chair (10-year tenure)
- Senior Scholar designation from Fonds de Recherche de Quebec
Professor Ernst maintains active mentorship of trainees across undergraduate to postdoctoral levels, with emphasis on creating excellent training environments in neurogenetics research. His laboratory collaborates extensively with clinical teams at McGill University Health Centre to connect basic research with patient care, particularly through engagement with families affected by rare neurodevelopmental disorders. Current research focuses on advancing therapeutic molecules toward Phase 1 clinical trials while developing improved cellular models of disease.
The Rare Neurodevelopmental Disorders Laboratory operates within The Neuro's integrated neuroscience ecosystem, leveraging resources from the Azrieli Centre for Autism Research and Neuro Open Science initiatives. Ernst's bilingual capabilities (English/French) facilitate collaboration across Quebec's research networks and clinical communities.
