معرفی
Calvin Vary is a Professor of Medicine at Tufts University School of Medicine and affiliated with both the Tufts Sackler School of Graduate Biomedical Sciences and the University of Maine Graduate School of Biomedical Science and Engineering (GSBSE). He serves as a Senior Scientist at the Maine Health Institute for Research (MHIR), directing the Proteomics and Lipidomics Core Facility. Dr. Vary's research focuses on BMP receptor signaling (ALK1/endoglin), angiogenesis, and tumor-microenvironment interactions using mass spectrometry-based omics approaches.
- Education:
- B.S., Biology, North Carolina State University
- Ph.D., Biological Chemistry, Michigan State University
His work explores molecular mechanisms in vascular development and pathology, particularly in hereditary hemorrhagic telangiectasia (HHT), and prostate cancer progression. Current projects analyze BMP9/10-dependent proteomic and secretomic changes in endothelial and cardiac progenitor cells. Dr. Vary has secured grants from the American Heart Association and NIGMS, including a multi-year COBRE grant for proteomics infrastructure.
Key contributions include elucidating Notch-BMP crosstalk in vascular biology, Risperidone-induced cardiac proteomic alterations, and endoglin's role in cancer-stromal interactions. He has mentored numerous MD fellows, postdoctoral researchers, and graduate students through his laboratory and institutional committees. Dr. Vary actively contributes to scientific governance as chair of the MHIR Institutional Biosafety Committee and co-chair of the MHIR IACUC.
