معرفی
Calvin Cole, Ph.D. is an Assistant Professor at the University of Rochester Medical Center (URMC) School of Medicine and Dentistry. He holds joint appointments in the Department of Surgery, Research, the Cancer Center, and the Department of Orthopaedics, Center for Musculoskeletal Research. Dr. Cole leads the Cole Lab, which focuses on investigating toxicities associated with Pancreatic cancer and Rheumatoid arthritis.
Dr. Cole's research centers on skeletal muscle wasting mechanisms in disease contexts, with particular emphasis on cancer cachexia and rheumatoid arthritis. His work integrates novel longitudinal imaging techniques including bioluminescence imaging (BLI) and dual energy x-ray absorptiometry (DEXA), combined with molecular approaches such as CRISPR gene editing, transcriptomics, and proteomics. A significant portion of his research investigates the role of IGFBP-3 in pancreatic cancer-related skeletal muscle wasting and tumor progression.
His laboratory has made important contributions to the validation of DEXA as a longitudinal outcome measure for both tumor burden and cancer-related muscle wasting in murine models. Recent work has also explored the relationship between exercise interventions and inflammatory conditions, examining how physical activity affects disease progression in models of rheumatoid arthritis and cancer. His research spans from molecular mechanisms to clinical applications, with a strong focus on translational approaches that bridge basic science with patient care.
Dr. Cole maintains an active publication record with high-impact research in cancer metabolism, skeletal muscle physiology, and exercise interventions for cancer-related toxicities. His collaborative work spans multiple disciplines and institutions, reflecting the interdisciplinary nature of his research.
As Principal Investigator of the Cole Lab, Dr. Cole mentors graduate students including Zachary Sechrist in the PhD Program in Pathology - Cell Biology of Disease. His research program is supported by various funding mechanisms, though specific grants are not detailed in the available information. The lab maintains active collaborations across multiple departments at URMC and with external institutions as evidenced by multi-institutional publications.
The Cole Lab is housed at 601 Elmwood Ave, Room 1.7534, Rochester, NY 14642, and maintains an active research program investigating the molecular mechanisms of disease-related skeletal muscle wasting, with ongoing projects focused on IGFBP-3 and PDAC-induced skeletal muscle wasting, validation of DEXA for tumor burden quantification, IGFBP-3 and PDAC tumor progression, and the relationship between rheumatoid arthritis, wheel running, and skeletal muscle wasting.
