Bryan Mounce

Bryan Mounce is an Associate Professor in the Department of Microbiology and Immunology at Loyola University Chicago's Stritch School of Medicine. He earned his B.S. from the University of Wisconsin-Madison, Ph.D. from the Medical College of Wisconsin, and completed postdoctoral training at the Pasteur Institute.

His research examines virus-host interactions at the metabolic interface, particularly how viruses and cells compete for polyamines—molecules critical for nucleic acid conformation, cell cycle regulation, and translation. His lab investigates how polyamines influence viral processes (genome translation, polymerase stimulation) and cellular responses to infection, with focus on viruses like Zika, Coxsackievirus, and vesicular stomatitis virus. Therapeutic strategies include targeting polyamine biosynthesis to inhibit viral replication.

Recent publications demonstrate a consistent focus on polyamine-mediated mechanisms across diverse viruses including HIV, coronaviruses, and bunyaviruses. Work from 2020-2025 explores polyamine roles in viral attachment/replication, metabolic manipulation, antiviral drug development (masitinib, bisacodyl), and resistance mechanisms. The research bridges virology, metabolism, and therapeutic design.