معرفی
Brian Bacskai is a Professor of Neurology at Harvard Medical School and a Principal Investigator in the Department of Neurology at Massachusetts General Hospital. His research focuses on developing advanced optical imaging techniques to study Alzheimer's disease in living transgenic mouse models.
- Specializes in multiphoton microscopy for in vivo imaging of senile plaques
- Develops novel optical methods like FLIM and NIR fluorescence tomography
- Investigates cellular responses to amyloid pathology and neurovascular unit dynamics
Current work emphasizes optimizing immunotherapies, characterizing amyloid-targeting ligands, and studying neurovascular interactions in Alzheimer's disease. The lab employs chronic imaging approaches to track disease progression and therapeutic outcomes. Key technical developments include:
- Fluorescence lifetime imaging microscopy (FLIM) for protein-protein interactions
- Non-invasive near-infrared (NIR) imaging for amyloid detection
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