Bombaci Alessandro

Bombaci Alessandro serves as a fixed-term Researcher in the Department of Neurology at Vita-Salute San Raffaele University's School of Medicine, actively engaged in both clinical research and medical education. His institutional affiliations include core responsibilities within the university's Neurology division and teaching roles across multiple medical programs.

His research program centers on translational neurology with dual pillars: amyotrophic lateral sclerosis (ALS) pathophysiology and sleep-related neurological disorders. Key investigation areas include respiratory failure biomarkers in ALS (serum chloride, cMVV), environmental and genetic factors in disease pathogenesis, neuroimmunological mechanisms, and clinical manifestations of sleep disorders including REM behavior abnormalities and obstructive apnea. His work bridges basic science with immediate clinical applications, particularly in diagnostic challenges like rheumatoid meningitis.

Analysis of his 2022-2025 publications reveals a dominant focus on ALS (70% of recent work), characterized by rigorous clinical approaches spanning epidemiological mapping, biomarker validation, and psychosocial impact studies. His sleep medicine research demonstrates sophisticated polysomnographic analysis and explores metabolic-neurocognitive interactions. The portfolio shows consistent publication in high-impact specialty journals including Brain, Journal of Neurology, and Sleep Medicine, with strong emphasis on open-access dissemination.