Bert Vogelstein

Bert Vogelstein is a Professor of Oncology and Pathology at the Johns Hopkins School of Medicine and serves as Director of the Ludwig Center at the Sidney Kimmel Comprehensive Cancer Center. A Howard Hughes Medical Institute investigator, he is renowned for his groundbreaking work in cancer genomics, particularly in elucidating the somatic evolution of tumors.

• University of Pennsylvania (B.A.)
• Johns Hopkins School of Medicine (M.D.)

His research focuses on:

• Colorectal cancer genetics
• Tumor suppressor genes (e.g., TP53, APC)
• Liquid biopsy technologies (Digital PCR, BEAMing, SafeSeqS)
• Mathematical models of cancer evolution
• Genomic instability in hereditary cancers

His recent publications emphasize liquid biopsies for cancer detection, exomic sequencing of tumors, and mathematical modeling of therapy resistance. Key trends include precision oncology, mutation profiling, and non-invasive diagnostic methods.

Scientific awards include:

• Breakthrough Prize (2013)
• Warren Triennial Prize (2014)
• Japan Prize (2021)
• Gruber Prize (2019)
• Dan David Prize (2018)

Vogelstein has mentored key researchers like Kenneth Kinzler and Victor Velculescu. His work has been supported by major grants from the Howard Hughes Medical Institute and Ludwig Center.

He leads the Vogelstein-Kinzler Lab at Johns Hopkins, which has pioneered cancer genomics and liquid biopsy technologies. The lab collaborates with institutions like Harvard University and Technion on interdisciplinary cancer research.