Benjamin C. Calhoun

Benjamin C. Calhoun, MD, PhD is an Associate Professor in the Department of Pathology and Laboratory Medicine at the UNC School of Medicine. As a UNC Lineberger Comprehensive Cancer Center member, his work focuses on tissue-based translational breast cancer research, particularly benign breast disease and machine learning applications in tumor prognosis.

• Director, Breast Pathology
• Core C Director, UNC Breast SPORE
• Faculty Advisor, Tissue Procurement Facility

Research Interests include:

• Translational breast cancer pathology
• Benign breast disease classification
• Immune profiling of tumor microenvironments
• Neoadjuvant chemotherapy response assessment
• Machine learning in histopathological image analysis
• Racial disparities in breast cancer outcomes

His recent publications analyze:

• Genomic correlates of immune features in breast cancer
• Racial/age-related somatic mutation patterns
• Visual heterogeneity in tumor progression
• ER+/HER2- subtypes with high-risk features
• Impact of HER2 testing guidelines
• Post-pandemic cancer trends

Lab & Collaborations: Leads tissue procurement for the UNC Breast SPORE, collaborating on studies involving:

• Molecular epidemiology (Carolinas Breast Cancer Study)
• Immune microenvironment analysis
• Multi-institutional clinical trials
• Algorithm development for digital pathology