معرفی
Balakrishna Lokeshwar is a Professor at the Medical College of Georgia, Augusta University, with appointments across multiple departments including Medicine, Georgia Cancer Center, Urology, Surgery, and Biochemistry & Molecular Biology. As an NIH-funded cancer biologist with over 30 years of experience, his work spans prostate, bladder, and breast cancer research, with a focus on inflammation-cancer links and dietary chemoprevention.
- PhD from Indian Institute of Science (1984), Post-Doc at Washington University St. Louis
- Previously served at University of Miami (1989-2015)
- Current 5/8 appointment at Charlie Norwood VA Medical Center
Research interests center on:
- Pro-inflammatory protein roles (COX-2, IL-8, osteopontin) in tumor progression
- Chemokine receptor signaling (CXCRs, beta-arrestins) in metastasis
- Development of plant-derived anticancer compounds like Ericifolin and BIRM
- Mechanisms of chemoresistance in advanced bladder cancer
- Multi-targeted approaches against tumor-promoting inflammation
- Autoophagy regulation in cancer (via 2016 guidelines contribution)
Scientific contributions include:
- First identification of matrix metalloproteinase imbalance in prostate cancer
- Development of CMT-3/COL-3 tetracycline derivatives
- Characterization of beta-arrestin's role in stem cell-like phenotypes
- Establishment of dietary compounds (curcumin analogs, triterpenoids) as therapeutic agents
Academic service encompasses:
- Graduate Student Selection Committee, Augusta University (2020)
- Faculty Senate Award Committee, Augusta University (2020)
- Co-Program Director, Biochemistry and Cancer Biology Graduate Program
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