معرفی
Ayesha Alvero, MD, MSc, is a Professor in the Department of Obstetrics and Gynecology at Wayne State University School of Medicine and holds a secondary appointment in the Department of Oncology. Previously at Yale University School of Medicine, she focuses on molecular mechanisms of ovarian cancer stem cells, chemoresistance, and immunotherapy development.
- Education:
- B.S. in Biology, De La Salle University
- M.D., University of the East
- M.Sc. in Molecular and Cellular Biology, University of New Haven
- Post-doctoral training at Yale University
Research Interests:
Dr. Alvero investigates ovarian cancer recurrence through:
- Molecular pathways of apoptosis evasion
- Targetable alternative cell death mechanisms
- Tumor microenvironment interactions
- Immunotherapeutic approaches including CARG-2020
- Epigenetic reprogramming by exosomal miRNAs
- BRCA status and Wnt signaling relationships
Recent Research Trends:
Her publications emphasize:
- Metabolomic and multiomic analyses of ovarian cancer subtypes
- Role of sialylation and MDSCs in immune evasion
- Exosomal miR-421 and miR-214 in metastasis and therapy response
- CTGF and MNRR1 as regulatory hubs in EMT and survival
- Machine learning models for recurrence prediction
- CARG-2020 immunomodulatory mechanisms
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