معرفی
Ashley Moseman serves as an Assistant Professor of Integrative Immunobiology and Assistant Professor of Cell Biology at Duke University School of Medicine. She holds significant affiliations as a Faculty Network Member of the Duke Institute for Brain Sciences and a Member of the Duke Cancer Institute. Her pioneering research examines the delicate balance between neuronal function and immune protection at the olfactory neuroepithelial barrier, where sensory neurons directly interface with the external environment while protecting the central nervous system from pathogens.
Dr. Moseman completed her Ph.D. at Harvard University in 2011, establishing the foundation for her interdisciplinary career at the intersection of immunology and neuroscience.
Her research program focuses on understanding how immunological surveillance operates at the unique olfactory barrier, where neurons must contact the external environment to perform chemosensory functions while preventing pathogens from entering the CNS. The Moseman Lab employs cutting-edge multiphoton intravital imaging to visualize immune responses in vivo, revealing dynamic cellular interactions during viral infections and responses to pathogens like Naegleria fowleri. Current projects investigate olfactory barrier mechanisms, neuroimmune crosstalk, host-pathogen dynamics, and immune responses to deadly neurotropic pathogens.
Analysis of Dr. Moseman's publication record demonstrates a cohesive research trajectory centered on neuroimmunology and mucosal defense mechanisms. Her work spans fundamental immunological processes, host-pathogen interactions at neural interfaces, and translational applications for understanding neurological complications of infections. A significant portion of her recent research addresses SARS-CoV-2-related olfactory dysfunction and the immunological basis of pathogen invasion through the olfactory system into the central nervous system.
Dr. Moseman has secured substantial research funding including 'Using tissue-specific Naegleria opportunism to dissect olfactory immunity' (2025-2030), 'Characterizing olfactory plasma cell dynamics and survival niche within the upper airway' (2024-2029), and the 'Advanced Immunobiology Training Program for Surgeons' (2019-2029). She actively contributes to graduate education through the Medical Scientist Training Program (2022-2027) and teaches advanced immunology courses including IMMUNOL 736 and IMMUNOL 494.
The Moseman Lab represents a leading center for neuroimmunology research, utilizing in vivo imaging to visualize immune responses within the central nervous system. Their work has significant implications for understanding how pathogens breach neurological barriers and how the immune system protects the brain while preserving essential sensory functions, with potential applications for treating neurological infections and inflammatory conditions.
