معرفی
Arturo Lopez Castel is an Assistant Professor in the Department of Genetics at the Faculty of Biological Sciences, Universitat de València, where he is a key member of the Human Translational Genomics research group and affiliated with the Institute of Biotechnology and Biomedicine (BIOTECMED). His work bridges fundamental genetic mechanisms with translational applications in neuromuscular disorders.
His research centers on the molecular basis of nucleotide repeat expansion diseases, especially myotonic dystrophy types 1 and 2. Using Drosophila melanogaster as a model organism, he investigates genomic instability, DNA repair deficiencies, and RNA toxicity mechanisms. His studies extend to patient-derived cell lines and mouse models, enabling a comprehensive approach from bench to bedside. Key areas include CTG/CAG repeat instability, epigenetic modifications like CpG methylation, and the role of microRNAs in muscle atrophy.
Analysis of his recent publications reveals a strong trajectory in both mechanistic and therapeutic research. He has pioneered in vivo screening platforms, explored natural compounds such as boldine and stephanantherine for treatment, and contributed to understanding parent-of-origin effects in congenital transmission. His work integrates omics technologies and molecular pathology to identify novel biomarkers and therapeutic targets.
While no scientific awards are mentioned in the provided text, his sustained publication record in high-impact areas underscores his contributions to the field. He has supervised thesis work and is actively involved in drug development pipelines for myotonic dystrophy, reflecting a commitment to both academic mentorship and clinical translation.
Dr. Lopez Castel leads research within the GT Human Translational Genomics group, leveraging collaborative networks and multidisciplinary approaches to tackle complex genetic disorders. His lab combines genetic models, molecular assays, and pharmacological testing to advance understanding and treatment of repeat expansion diseases.
