Arthur Charles Riegel

Arthur Charles Riegel is an Associate Professor at the University of Arizona, affiliated with the Departments of Neuroscience, Optical Sciences, and Pharmacology. His research focuses on synaptic dysfunction in neurological and psychiatric disorders related to addiction, pain, and stress, with emphasis on GPCR regulation of brain circuitry and neuronal function through neuropeptides and intracellular signaling mechanisms.

Research activities span multiple scales of inquiry:

• Investigation of GPCR interactions (CRF, CB1, 5-HT receptors) and ion channels (CaV2.2, Kv7) in addiction and pain pathways
• Characterization of dopamine and GABA signaling in the ventral tegmental area (VTA) and prefrontal cortex
• Analysis of abused substances' effects on neurotransmitter systems (opioids, cocaine, cannabinoids, toluene)

The publication record reveals consistent focus on neurotransmitter signaling, addiction mechanisms, pain neurobiology, and receptor modulation over two decades, with recent work emphasizing therapeutic targeting of serotonin receptors and potassium channels for neuropathic pain.