Arielle Klepper

Arielle Klepper, MD, PhD, is an Assistant Professor of Medicine at the University of California, San Francisco (UCSF) School of Medicine. She specializes in gastroenterology and hepatology, focusing on autoimmune liver diseases and viral hepatitis. Her research investigates microbial and host interactions in liver disease progression, particularly the role of human herpesviruses in autoimmune hepatitis and hepatitis C virus (HCV) dynamics.

Education: Icahn School of Medicine at Mount Sinai (MD/PhD, 2016), followed by UCSF training in Internal Medicine Residency (2019), Chief Residency (2020), and Gastroenterology Fellowship (2024).

Research interests include:

• Sequencing-based analysis of ascites fluid microbiology
• Human herpesvirus contributions to autoimmune hepatitis
• Immune profiling in liver diseases
• HCV RNA persistence mechanisms

Awards: John A. Watson Faculty Scholars Award (2024-2027), Diversity in Biomedical Sciences Award (2020-2025). Leads the HALT clinic for alcohol-associated liver disease alongside Drs. Courtney Sherman and Treveni Defries.

Recent work focuses on identifying novel autoantibody targets in autoimmune hepatitis and optimizing immunotherapies, with 20+ peer-reviewed publications in journals like Hepatology and PLoS One.