Anthony K. Shum

Anthony K. Shum is a Professor of Medicine at the University of California, San Francisco (UCSF) School of Medicine, specializing in autoimmune lung diseases and Interstitial Lung Disease (ILD). He leads a basic-translational research program that investigates the intersection of autoimmunity and pulmonary disease, focusing on conditions like rheumatoid arthritis with lung manifestations. His lab develops next-generation sequencing pipelines to identify rare genetic variants in Mendelian autoimmune disorders and uses animal models to validate molecular mechanisms.

• Education: University of Chicago Pritzker School of Medicine (MD)

Shum’s research has uncovered lung-specific antigens and autoantibodies as biomarkers for autoimmune lung diseases. His team also identified the genetic basis of COPA syndrome, an inherited disorder causing lung and joint disease. His work emphasizes translational applications, linking molecular discoveries to patient diagnostics and therapies.

Recent publications highlight his contributions to understanding the STING pathway in autoimmunity, CDHR5 autoantibodies in ILD, and interferon scores as COPA syndrome biomarkers. His grants include NIH funding for COPA syndrome and autoimmune lung disease studies.

• Scientific Awards:
  • Rheumatology Research Foundation 2025 Innovative Research Award
  • American Society for Clinical Investigation 2022 Elected Member
  • Arthritis Foundation 2015 Lee Howley Sr. Prize
  • Will Rogers Institute 2005 Fellowship

Shum’s lab collaborates with the UCSF Immunology Program and Biomedical Sciences Graduate Program, offering clinical and research expertise in autoimmune pulmonary disorders. He actively enrolls patients with COPA syndrome and related conditions for genetic and immunological studies.