Annette Eva Langkilde

Annette Eva Langkilde is an Associate Professor in the Department of Drug Design and Pharmacology at the University of Copenhagen's Faculty of Health and Medical Sciences. Her research focuses on structural analysis of proteins in solution with particular emphasis on fibrillation processes leading to amyloids and amyloid-like structures. She leads work within the BioSAXS group where small-angle X-ray scattering (SAXS) serves as the primary methodology for obtaining structural information, complemented by various biophysical techniques, transmission electron microscopy (TEM), and fiber diffraction.

Langkilde's research interests center on protein structure and dynamics, particularly related to neurodegenerative diseases. Her work investigates amyloid formation mechanisms, protein misfolding, and the structural basis of protein aggregation. She has developed expertise in SAXS data analysis for developing protein systems, with significant contributions to understanding α-synuclein behavior in various contexts including its effects on neuronal calcium signaling, cell death mechanisms, and interactions with neurotransmitter systems. Her research bridges structural biology with neurobiology, providing insights into the molecular mechanisms underlying protein aggregation diseases.

Analysis of her recent publications reveals a strong focus on α-synuclein pathology across multiple biological contexts, with particular attention to sex differences in neuronal responses, connections to sleep regulation, and interactions with calcium homeostasis. Her work demonstrates integration of structural biology with cellular and physiological approaches, showing how molecular-level protein behavior translates to cellular dysfunction in neurodegenerative conditions.

Langkilde has contributed to research-integrating teaching methodologies, particularly using intrinsically disordered proteins as educational tools. While specific grant information isn't detailed in the provided text, her extensive publication record across multiple high-impact journals suggests successful research funding. She appears to be actively collaborating with numerous researchers across different institutions, as evidenced by her broad co-authorship patterns.

She leads research within the BioSAXS group, which specializes in applying small-angle X-ray scattering to protein structural analysis. Her laboratory likely maintains capabilities for complementary biophysical characterization and collaborates with groups possessing specialized equipment for techniques like neutron crystallography, TEM, and advanced cellular imaging necessary for her multidisciplinary research approach.