Annemarie Dedek

Annemarie Dedek is an Assistant Professor at the University of Waterloo. Her research focuses on understanding molecular and cellular mechanisms underlying chronic pain, with particular emphasis on spinal cord pathways and sex-based differences in pain processing. She investigates the roles of ion channels (e.g., T-type calcium channels, NMDA receptors), neurotransmitter systems (e.g., endocannabinoids), and hormonal influences in pain modulation. Her work bridges preclinical rodent models and human spinal cord studies to advance translational pain therapies. Key areas include spinal hyperexcitability, opioid-induced neuroplasticity, and presynaptic receptor dynamics.

Her recent publications explore topics such as CaV3.2 channel facilitation in hyperalgesia, KCC2 deficits in chronic pain, and the role of gonadal hormones in pain modulation. Methodological contributions include developing assays for dorsal root ganglion characterization and addressing variability in rodent pain behavior testing.

Dr. Dedek’s research also intersects with clinical applications, including the effects of ketamine infusions and cannabinoid receptor localization in pain pathways. Her work emphasizes rigorous translational approaches to bridge basic science and clinical pain management strategies.