معرفی
Anne Kenworthy is a Professor in the Department of Molecular Physiology and Biological Physics at the University of Virginia. Her research focuses on the architecture and function of biological membranes, with a particular emphasis on lipid rafts and caveolae in health and disease.
- Primary Appointment: Professor, Molecular Physiology and Biological Physics, University of Virginia
- Education: BA in Biology from Kenyon College, PhD in Cell Biology from Duke University School of Medicine
- Postdoctoral Training: Biophysics at Johns Hopkins University, Cell Biology at NIH
Her work combines live cell imaging, biophysics, structural analysis, and biochemical approaches to investigate:
- How proteins and lipids cooperate to form lipid rafts
- Exploitation of rafts by bacterial toxins
- Cholesterol's role in Alzheimer's disease
- Caveolin-1 mutations in breast cancer and pulmonary hypertension
- Structural basis for caveolae formation
Recent studies highlight lipid peroxidation effects on phase separation, caveolin mutation structural analysis, and toxin-membrane interactions. She has contributed extensively to understanding membrane microdomains through 15 recent publications spanning 2024–2020.
Her lab employs advanced techniques including:
- Fluorescence Recovery After Photobleaching (FRAP)
- Single Particle Electron Microscopy
- AlphaFold2 Structural Prediction
- High-Content Imaging Platforms
The research has implications for neurodegenerative diseases, cancer, and infectious disease mechanisms.
