معرفی
Anna Orr is an Assistant Professor at Weill Cornell Medicine's Graduate School of Medical Sciences and holds the Nan and Stephen Swid Endowed Professorship of Frontotemporal Dementia Research. The Orr lab investigates glial-neuronal interactions with a focus on astrocytes and mitochondria as therapeutic targets for neurocognitive impairments in FTD, AD, and related disorders.
- Emory University (PhD in Neuroscience)
- Gladstone Institutes/UCSF (Postdoctoral Research Fellow)
Research interests include:
- Mechanisms of glial-neuronal interactions in neurodegenerative diseases
- Mitochondrial reactive oxygen species (ROS) production and regulation
- Sex-specific cognitive modulation via astrocytic receptor signaling
- Antiviral pathway disruptions in dementia
- Translational approaches using transgenic models and omic technologies
- Therapeutic targeting of neuroimmune and redox pathways
Notable article trends:
- Sex-dimorphic effects of astrocytic receptors on memory
- Neuroimmune signaling in nucleocytoplasmic disruptions
- TDP-43 pathology in astrocyte antiviral pathways
- Mitochondrial ROS contributions to dementia pathology
- Multi-omics approaches to identify therapeutic targets
Scientific awards:
- 2021 Outstanding Neuroscience Teaching and Mentoring Award
- 2021 Nan and Stephen Swid Endowed Professorship
- Accelerating Drug Discovery for FTD Grant (AFTD/ADDF)
Lab members include graduate students Daniel Barnett (Glial biology), Laraib Ijaz (Gliopathophysiology), Caroline Booraem (Oxidative stress), Evelyn Hardin (Neuroimmune interactions), Alicia Whye (GPCR roles in memory), and postdoctoral researchers Minwoo Wendy Jang and Pedro Negri Bernardino. The lab is part of the Brain and Mind Research Institute and collaborates with the Appel Alzheimer's Disease Research Institute.
