Anna C. Aschenbrenner

Dr. Anna C. Aschenbrenner serves as a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, affiliated with the University of Bonn's Medical Faculty. Her research centers on the immune system's role in ageing processes and age-related diseases, particularly neurodegenerative conditions.

Her work investigates immune ageing mechanisms, chronic inflammation in elderly populations, and infections (HIV, sepsis, acute/post-COVID syndromes) as triggers for premature immune deterioration. She employs advanced immunology, functional genomics, and AI-driven bioinformatics to analyze high-dimensional cohort data, developing precision medicine tools like companion diagnostics for corticosteroid therapies in critical care.

Her 2024 Cell publication demonstrates how dexamethasone-induced monocyte transcriptional changes directly correlate with severe COVID-19 outcomes, establishing a framework for identifying therapy non-responders through single-cell omics.

Dr. Aschenbrenner leads multiple cohort studies (HIV2000, ImmunoSEP, DeCOI, NEUROCOV, NKSG, IMMME) characterizing immune responses across infectious diseases. Her group conducts intervention research on elderly vaccination optimization, drug repurposing for immune enhancement, and functional genomics-based diagnostic development.

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