Ann Gregus

Dr. Ann Gregus is an Assistant Professor at the School of Neuroscience within Virginia Tech's College of Science. With over 15 years of experience in academia and pharmaceutical research, she specializes in elucidating molecular mechanisms of chronic pain and developing nonopioid therapeutics through collaborative projects with the Buczynski laboratory.

• PhD in Pharmacology, Weill Cornell Graduate School of Biomedical Sciences
• BS in Biology, Villanova University

Her research integrates advanced mass spectrometry, cell-based assays, and behavioral pharmacology to investigate:

• Translational drug discovery for pain
• Endocannabinoid signaling pathways
• Sex differences in pain mechanisms
• Neuroimmune interactions in chronic pain
• Molecular basis of drug tolerance
• Multi-omic pain biomarker identification

Recent publications demonstrate her focus on:

• 2025: Ethanol-pain interactions
• 2024: Nicotine vapor's behavioral effects
• 2023: Secernin-3 in thermal pain
• 2023: NAPE-PLD in affective pain
• 2022: Addiction parallels in food/drug reward

Dr. Gregus leads collaborative efforts with:

• Buczynski Research Group
• Frailin Biomedical Research Institute
• Virginia Tech Life Sciences campus