معرفی
Anja Nagel is an Adjunct Professor in the Department of Genetics at the University of Hohenheim, where she leads research on molecular mechanisms of stem cell resilience. Her work focuses on genome integrity, cellular differentiation, growth regulation, and immunity using Drosophila as a model organism. She applies advanced molecular techniques including CRISPR/Cas9 genome engineering to investigate fundamental biological processes with potential therapeutic applications, particularly in leukemia research.
Dr. Nagel's primary research interests center on three interconnected areas: the role of the putzig gene in growth regulation and epigenetic control of genome stability in germ line stem cells; DNA repair mechanisms in Drosophila with relevance to human diseases like cancer; and the Notch signaling pathway's role in hematopoiesis and immune cell differentiation. Her laboratory has made significant contributions to understanding how post-translational modifications, particularly phosphorylation, regulate Notch signaling activity through the CSL/Su(H) transcription factor.
Analysis of her recent publications reveals a consistent focus on Notch signaling pathway mechanisms, with increasing emphasis on the intersection between immune response and developmental processes. Her work demonstrates how Drosophila genetics can illuminate conserved molecular pathways relevant to human health, particularly in blood cell development and cancer biology. The research employs sophisticated genetic approaches including CRISPR/Cas9 genome editing, phospho-specific mutations, and detailed phenotypic analyses.
Dr. Nagel's research is supported by the German Research Foundation (DFG), with current projects specifically funded under grants NA 427/6-1 (focusing on putzig and genome stability) and NA 427/5-1 (investigating Notch signaling in hematopoiesis). Her laboratory maintains an active research program with consistent publication output spanning from fundamental genetic discoveries to potential therapeutic applications.
