Anita Rauch

Anita Rauch is a Full Professor of Medical Genetics and Director of the Institute of Medical Genetics at the University of Zurich. Her research focuses on the genetic and molecular mechanisms underlying severe neurodevelopmental disorders and hereditary breast cancer, utilizing genome sequencing and human induced pluripotent stem cell (iPSC) models.

• Current projects include:
• Genetic causes and molecular mechanisms in severe intellectual disability
• Praeclare (genetic variant clarification for prenatal medicine)
• SwissGenVar (clinical genetic variant interpretation platform)
• Hereditary breast cancer in Switzerland

Her work is funded by the Swiss National Science Foundation (SNSF). She leads a multidisciplinary team conducting functional studies on novel candidate genes (e.g., CYFIP2, TMEM94) and exploring genotype-phenotype correlations through iPSC-derived neuronal models.

Key research trends in her publications include:

• Clinical trials for cancer therapies (colon, esophageal, pancreatic, breast)
• Pharmacogenetic determinants of chemotherapy toxicity
• Non-inferiority trial design methodology
• Genetic variant interpretation in personalized medicine

She mentors PhD and Master’s students in medical genetics and contributes to the advancement of precision oncology and neurogenetics through translational research.