Andrew J. Fisher

Andrew J. Fisher is a Professor at the University of California, Davis, affiliated with the Department of Chemistry and Department of Molecular and Cellular Biology. His research focuses on elucidating the structure-function relationships of biologically important macromolecules through X-ray crystallography and Cryo-EM, with emphasis on RNA editing by ADARs, sulfate activation, and glycobiology.

• Education: Ph.D. in Biophysics (1992, Purdue University), B.S. in Biochemistry (1987, Purdue University)
• Professional History: UC Davis faculty since 1996; NIH Postdoctoral Fellow at University of Wisconsin-Madison (1992-1996)

His structural biology research spans:

• ADAR enzyme mechanisms in RNA editing
• Enzymatic pathways in sulfate activation
• Carbohydrate metabolism and glycoprotein modification
• Calcium signaling complex structures
• Toxin-receptor interactions
• Photoreceptor protein dynamics

Publications reveal a career-long focus on structural enzymology, nucleic acid-protein interactions, and biophysical techniques. His 2010-2024 work includes studies on:

• RNA editing guide strand optimization
• ADAR mutation pathogenesis
• Cellobiose epimerase catalytic cycles
• Neisseria meningitidis enzyme characterization
• Calmodulin-RyR2 calcium binding
• Cyanobacteriochrome spectral tuning

• Scientific Awards: Linus Pauling Prize (1991)

He leads the Fisher Lab at UC Davis, contributing to biomedical imaging tools, neurochemical sensors, and carbohydrate-active enzyme research. His collaborations include work on:

• Arabidopsis BIK1 kinase defense signaling
• Fullerene chemistry
• Cas9-based RNA editing
• Flagellar calcium-binding protein targeting