معرفی
Andreja Ambriović Ristov is a senior scientist and Head of the Laboratory for Cell Biology and Signal Transduction at the Department of Molecular Biology, Ruđer Bošković Institute in Zagreb, Croatia. She holds a Ph.D. and serves as a Scientific Advisor in Permanent Position, indicating a high-ranking research role equivalent to full professor in academic institutions. Her work is centered on molecular mechanisms of cancer progression and therapy resistance.
Research Interests:
Her primary research focuses on integrin-mediated signaling in cancer cells, particularly the roles of αvβ3 and αvβ5 integrins in drug resistance, cell adhesion, migration, and survival. She investigates how these integrins modulate responses to chemotherapy and radiation, with a strong emphasis on adenoviral vectors for gene therapy and the regulation of focal and reticular adhesions. Her work also extends to oxidative stress, apoptosis, and the tumor microenvironment.
Publication Trends:
Analysis of her recent publications (2020–2024) reveals a consistent focus on integrin crosstalk, extracellular matrix interactions, and cytoskeletal dynamics in cancers such as melanoma, prostate, and breast cancer. She frequently explores how adhesion complexes influence sensitivity to microtubule poisons and radiotherapy, often in collaboration with international teams. Her studies combine molecular biology, cell imaging, and functional assays to dissect signaling networks.
Academic Mentoring and Supervision:
She has actively mentored numerous graduate and doctoral students, as evidenced by the list of theses where she is listed as mentor. These students have worked on topics such as integrin silencing, adenoviral transduction, and chemoresistance mechanisms, reflecting the breadth and depth of her research group’s activities.
Laboratory and Collaborations:
She leads a dynamic research team within the Laboratory for Cell Biology and Signal Transduction, collaborating with researchers across Europe. Her lab utilizes advanced techniques in molecular and cellular biology to study cancer cell behavior and therapeutic responses.
