Andrea Sinz

Andrea Sinz is a Full Professor and head of the Department of Pharmaceutical Chemistry and Bioanalytics at Martin Luther University Halle-Wittenberg (MLU). She holds a Pharmacy degree from the University of Tübingen (1993) and a PhD in Pharmaceutical Chemistry from the University of Marburg (1997). Her postdoctoral work at the NIH introduced her to chemical cross-linking and mass spectrometry (MS), which became her core research focus. She leads the Research Training Group (RTG) 2467, focusing on protein interactions of tumor suppressor p53, and served as DGMS president (2017–2020).

Her research emphasizes cross-linking/MS method development for studying protein conformations and interactions. Key innovations include MS-cleavable cross-linkers and the MeroX software. Applications span cancer biology, neurology, and virology, with recent work exploring therapeutic vulnerabilities in leukemia and non-coding RNA roles in disease.

Publications highlight cross-disciplinary impacts, from structural proteomics to clinical efficacy studies of theophylline in ADCY5 dyskinesia. Her lab collaborates globally to advance proteomic data standards and integrative approaches combining cryo-EM, computational modeling, and MS.