معرفی
Andrea Califano is the Clyde and Helen Wu Professor of Chemical and Systems Biology at Columbia University, holding joint appointments in the Departments of Biomedical Informatics, Biochemistry & Molecular Biophysics, and Medicine. He is the founding chair of the Department of Systems Biology at Columbia University Irving Medical Center and directs the JP Sulzberger Columbia Genome Center and the Herbert Irving Comprehensive Cancer Center's bioinformatics division. A physicist-turned-biologist, his research focuses on systems biology approaches to identify master regulator proteins in cancer, enabling precision medicine strategies such as N-of-1 clinical trials. His lab develops computational tools like ARACNe, MARINa, and VIPER to model regulatory networks and drug mechanisms.
Research interests include tumor progression, drug resistance, and cancer immunology. He pioneered network-based methods to target cancer dependencies beyond genetic mutations, emphasizing regulatory bottlenecks. His work bridges computational models with experimental validation, leading to clinical trials for drugs like entinostat in neuroendocrine tumors. Awards include AAAS, ISCB, and IEEE fellowships, and National Academy of Medicine membership (2018).
- Education: Physics training with a focus on computational biology
- Affiliations: JP Sulzberger Genome Center, Herbert Irving Cancer Center
- Grants: NCI, Lustgarten Foundation, Falconwood Foundation
- Labs/Teams: Califano Systems Biology Lab, leading 20+ researchers
Current efforts include single-cell analysis of tumor heterogeneity and developing therapies targeting master regulators in pancreatic, prostate, and glioblastoma cancers. He co-founded DarwinHealth to translate computational findings into clinical solutions.
