معرفی
Dr. Andre Kahles is a Lecturer in the Department of Computer Science at ETH Zürich, specializing in biomedical informatics. His research focuses on computational methods for analyzing large-scale genomic and transcriptomic data, with applications in cancer genomics, metagenomics, and precision medicine. He has contributed to the development of tools such as SplAdder for alternative splicing analysis, MetaGraph for petascale genomic data exploration, and SECEDO for subclone detection in cancer genomes. His work bridges algorithmic innovation with biological insights, addressing challenges in single-cell analysis, genome graph alignment, and multi-omics integration.
Key research themes include:
- Developing scalable algorithms for processing nanopore sequencing and metagenomic data
- Characterizing somatic mutations and non-coding drivers in cancer genomes
- Advancing genome graph-based alignment and annotation methods
- Integrating multi-omics data for clinical decision-making and tumor profiling
His publications span topics like RNA-seq analysis, chromothripsis in cancers, and global urban microbiome tracking through the MetaSUB consortium. Kahles has collaborated on landmark projects including the Pan-Cancer Analysis of Whole Genomes (PCAWG) and the Tumor Profiler Study.
