معرفی
Dr. Amir Enshaei is a researcher at Newcastle University, specializing in genomic and molecular characterization of acute lymphoblastic leukemia (ALL). His work focuses on integrating genetic data, cytogenetic abnormalities, and clinical outcomes to refine risk stratification models for pediatric and adult ALL patients.
- Key Research Areas:
- Chromosomal abnormalities in ALL (e.g., IG-MYC rearrangements, IKZF1 deletions)
- Risk stratification through minimal residual disease (MRD) and copy number alterations
- Targeted therapies for blast-phase myeloproliferative neoplasms
- Application of molecular profiling in clinical trials (UKALL97/99, UKALL14, UKALL2003)
- Recent Publications:
- 2025: Chromothripsis and DYRK1A overexpression in MPN transformation
- 2024: Integrated prognostic index for adult ALL (EWALL study)
- 2023: TP53 abnormalities in pediatric B-NHL, FOXO-PRDM1 axis disruptions
His research emphasizes stratified medicine and prognostic modeling, often collaborating on large-scale studies using platforms like HARMONY and UKALL trials.
۰مقاله منتشرشده
