Amelie Stein

Amelie Stein is an Associate Professor at the Department of Biology, University of Copenhagen, specializing in Bioinformatics and RNA Biology. Her research focuses on protein stability, molecular mechanisms of disease variants, and computational methods for protein design. She is affiliated with the UCPH Quantum Hub, reflecting interdisciplinary interests in biological systems. Her work integrates bioinformatics tools, mutational scanning, and structural biology to understand protein degradation pathways and their relevance to human diseases such as Lynch syndrome and metabolic disorders.

Key research areas include analyzing protein variants using deep learning models (e.g., SSEmb), developing web-based tools like MutationExplorer for 3D visualization, and characterizing disease-linked mutations in proteins such as Parkin and MLH1. Her publications highlight breakthroughs in rapid protein stability predictions, degon mapping, and the interplay between protein toxicity and degradation.

No scientific awards are explicitly mentioned in the provided texts. Stein’s research also explores the application of computational approaches to biotechnology and therapeutic development, emphasizing translational applications of her findings.

Her lab, linked to the SCARB research group (https://www1.bio.ku.dk/english/research/scarb/), focuses on structural and computational biology, with ongoing projects involving protein quality control networks and enzyme variant analysis. Collaborations span molecular biology, bioinformatics, and interdisciplinary quantum-related research through her UCPH Quantum Hub membership.