Amanda Trout

Amanda Trout is a Research Assistant Professor in the Department of Neurosurgery at the University of Kentucky College of Medicine, with affiliations to SCOBIRC (Faculty Associates). Her work focuses on cerebrovascular disease pathophysiology, stroke biomarkers, and neuroprotective strategies. Key research themes include proteomic profiling of stroke patients undergoing mechanical thrombectomy, extracellular vesicle-mediated signaling in neurodegeneration, and sex-specific differences in stroke outcomes.

Her publications (2021–2025) emphasize translational stroke research, with studies exploring inflammatory biomarkers (e.g., VCAM1, REG3A), neuroprotective agents (interleukin-1α, ATN-161), and the role of extracellular vesicles in cerebrovascular disorders. Collaborations like the BACTRAC (Blood and Clot Thrombectomy Registry and Collaboration) protocol highlight her engagement in large-scale clinical proteomic studies.

• Awards: None explicitly listed.
• Grants/Labs: Active involvement in BACTRAC and studies on perlecan domain V’s neuroprotective effects in vascular dementia models.

Dr. Trout’s work bridges basic science and clinical practice, addressing critical gaps in understanding stroke pathophysiology and improving therapeutic strategies for ischemic stroke patients.