Aman Ishaqat

Aman Ishaqat is a researcher at the Institute of Technical and Macromolecular Chemistry (RWTH Aachen University) and affiliated with the DWI – Leibniz Institute for Interactive Materials. His work focuses on polymer mechanochemistry, particularly in biomedical contexts using ultrasound-responsive polynucleotide-based delivery systems. Key research contributions include the development of rolling circle amplification (RCA)-derived DNA polymers for controlled release of therapeutic oligonucleotides and small molecules via medical imaging ultrasound.

• Key Disciplines: Polymer Chemistry, Mechanochemistry, Biomedical Engineering

The 2024 Advanced Materials study he co-authored introduces a universal polynucleotide framework for ultrasound-mediated cargo release, demonstrating applications in immunostimulation and gene knockdown both in vitro and in vivo. The system leverages DNA nanoflowers and hydrogel matrices for mechanochemical activation without requiring exogenous microbubbles.