معرفی
Alina Üffing is a researcher at the Institut für Physikalische Biologie (Heinrich-Heine-Universität Düsseldorf) and Forschungszentrum Jülich (IBI-7). Her work focuses on the molecular mechanisms of autophagy-related proteins, particularly the GABARAP subfamily's interaction with receptors like EGFR.
- Key Research Areas:
- Structural analysis of GABARAP-EGFR binding
- Role of LC3-interacting regions (LIRs) in receptor trafficking
- Autophagy in neurodegenerative diseases and cancer
Notable Contributions: Crystallography of the EGFR LIR1-GABARAP complex (PDB: 8S1M), biolayer interferometry (BLI) quantification of binding affinities, and NMR chemical shift perturbation (CSP) mapping. Her studies demonstrate GABARAP's unique role in EGFR stabilization via non-canonical LIR docking, independent of canonical residues Y49/L50.
Collaborations: Integral member of teams led by Dieter Willbold and Silke Hoffmann, contributing to projects on autophagy's intersection with endocytic pathways and RTK signaling. Her work bridges structural biochemistry with cellular outcomes in receptor degradation and signaling.
