Alexander Chubykin

Alexander Chubykin is an Associate Professor in the Department of Biological Sciences at Purdue University, part of the College of Science. His research focuses on neural circuits in the mouse visual cortex, synaptic plasticity, and optogenetic techniques to study autism and neural circuit dysfunction. Chubykin employs advanced imaging and electrophysiological methods to investigate how neuromodulatory systems influence visual perception and reward-dependent plasticity.

His work integrates in vitro and in vivo approaches, including automated patch-clamp electrophysiology and optogenetics, to dissect neural circuit mechanisms. Key research areas include the role of neuroligins and neurexins in synapse formation, and the application of adaptive optics for high-resolution microscopy in thick tissues. Chubykin has developed novel wireless neural recording devices and contributed to neurotechnology advancements such as deep learning-driven adaptive optics for single-molecule localization microscopy.

Publications highlight his contributions to understanding visual cortex plasticity in autism models, potassium channel roles in zebrafish fin patterning, and interdisciplinary studies combining materials science with neurobiology. His lab’s innovations span from molecular mechanisms to translational neurotechnology, with applications in brain-inspired computing and neural circuit restoration after injury.