Alessandro Gulberti

Alessandro Gulberti is a Research Fellow in the Department of Neurology at the Universitätsklinikum Eppendorf (UKE) in Hamburg, affiliated with the Faculty of Medicine. His work focuses on the neurophysiological and clinical aspects of Parkinson’s disease, particularly the effects of deep brain stimulation (DBS) on motor and cognitive functions. He investigates neural mechanisms underlying gait disorders, speech impairment, and cognitive deficits in Parkinson’s patients, leveraging advanced techniques like electrophysiology, neuroimaging, and computational modeling.

Key research interests include DBS efficacy in modulating cortical and subcortical networks, the role of beta oscillations in Parkinsonian symptoms, and the application of virtual reality for gait rehabilitation. His studies often involve collaborations with neurologists, neurosurgeons, and engineers to optimize DBS protocols and understand disease mechanisms. Gulberti’s work has contributed to understanding the anatomical and functional targets of DBS, such as the subthalamic nucleus and substantia nigra, and their impact on axial symptoms, speech, and cognitive performance.

Publications highlight his exploration of DBS-induced changes in neural networks, including studies on gait symmetry, pupil fluctuations in progressive supranuclear palsy, and the use of theta-burst stimulation. He has also evaluated the perioperative effects of safinamide in DBS patients and developed frameworks for improving eye-tracking data quality. His research bridges clinical neurology with translational neuroscience, aiming to enhance therapeutic outcomes through precision stimulation and personalized medicine.