معرفی
Alejandro Pablo Adam is an Associate Professor in the Department of Molecular and Cellular Physiology at Albany Medical College. His research focuses on the pathophysiology of disproportionate inflammatory responses, emphasizing vascular permeability and organ dysfunction in conditions like sepsis, rosacea, and uveitis. He leads a lab dedicated to identifying therapeutic targets for excessive inflammation and tissue damage.
Education:
- PhD, University of Buenos Aires (2007)
- BS/MS, University of Buenos Aires (1999)
Dr. Adam's research explores both acute and sustained mechanisms of vascular leakage caused by cytokines such as IL-6 and TNF-α. Key areas include STAT3 signaling in endothelial cells, epigenetic responses in shock, and the role of adherens junctions in inflammation. His work bridges molecular studies with translational clinical trials, particularly for ocular rosacea.
His recent publications and ongoing studies highlight advancements in understanding
- cytokine-driven vascular dysfunction,
- innate immunity in chronic inflammation,
- and novel anti-inflammatory therapeutics.
Scientific Awards & Funding:
- NIGMS R35 Award (2024) for endothelial signaling research
- NIH/NIGMS grants supporting vascular leakage and angiogenesis studies
Dr. Adam's lab employs cutting-edge techniques like Airyscan and STED microscopy to investigate endothelial junction dynamics. Collaborative projects span pre-eclampsia, chorioretinal diseases, and sepsis models, with mentorship provided to PhD students like Shuhan Lu and postdoctoral fellows.
