معرفی
Alan Lambowitz is a distinguished Professor of Molecular Biosciences at the University of Texas at Austin, holding the prestigious Mr. and Mrs. A. Frank Smith, Jr. Regents Chair in Molecular Biology. Since 1997, he has been a key faculty member in the Department of Molecular Biosciences within the College of Natural Sciences. In 2019, he expanded his academic role to include Professor of Oncology at the Dell Medical School. From 1997 to 2016, he served as Director of the Institute for Cellular and Molecular Biology, demonstrating significant leadership in advancing molecular research at UT Austin.
Lambowitz earned his B.S. in Chemistry from Brooklyn College in 1968, graduating Summa cum laude with honors. He continued his education at Yale University, where he received his M. Phil. in 1970 and Ph.D. in Molecular Biophysics and Biochemistry in 1972, completing his doctoral work under the supervision of Professor Carolyn Slayman. His postdoctoral training included a fellowship at the University of Pennsylvania's Johnson Research Foundation and positions at Rockefeller University and the National Institute of Mental Health.
Professor Lambowitz's research focuses on group II intron and related bacterial and organellar reverse transcriptases (RTs), examining their reverse transcription mechanisms, association with CRISPR-Cas systems, and applications in high-throughput RNA sequencing (RNA-seq). His laboratory employs a multidisciplinary approach combining genetic, biochemical, microbiological, and structural methods, including X-ray crystallography, cryo-EM, and advanced bioinformatic techniques for analyzing sequence data and identifying biomarkers in clinical samples. His work has significant implications for RNA diagnostics and liquid biopsy applications in human diseases.
Analysis of his recent publications reveals a strong emphasis on RNA biology, particularly in understanding intron processing, RNA structure, and the development of novel RNA sequencing technologies. His research bridges fundamental molecular mechanisms with clinical applications, particularly in cancer diagnostics and biomarker discovery through liquid biopsy approaches. The consistent focus on reverse transcriptases and RNA processing across his publication history demonstrates a cohesive research trajectory spanning several decades.
- Member, National Academy of Sciences, 2004
- Fellow, American Academy of Arts and Sciences, 1995
- Fellow, American Association for the Advancement of Science, 2001
- Wilbur Cross Medal, Yale University, 2013
- Member, The Academy of Medicine, Engineering, and Science of Texas, 2004
- Fellow, American Academy of Microbiology, 2004
Lambowitz has maintained extensive editorial and advisory roles throughout his career, serving on the editorial boards of numerous prestigious journals including Molecular and Cellular Biology, RNA, and Proceedings of the National Academy of Sciences. His laboratory at UT Austin continues to be a center of innovation in RNA biology, with ongoing clinical trials focused on RNA diagnostics. The Lambowitz Lab employs cutting-edge techniques to investigate RNA structure, function, and applications, maintaining a strong collaborative environment that bridges basic science and translational research.
