معرفی
Adrian Goldman is a Professor at the University of Helsinki, Faculty of Biological and Environmental Sciences, working within the Molecular and Integrative Biosciences Research Programme. His research focuses on membrane proteins and protein complexes at or near the cell surface, with significant contributions to structural biology and biochemistry. He holds positions as supervisor for multiple doctoral programmes including the Doctoral Programme in Plant Sciences, Doctoral Programme Brain & Mind, and Doctoral Programme in Integrative Life Science.
Professor Goldman's research interests center on membrane protein systems, which are targeted by more than 50% of current drugs. His work spans neuronal protein interactions (including GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and host-pathogen interactions involving trimeric autotransporters, factor H, and complement. He has developed expertise in studying membrane proteins using advanced techniques that allow for lower amounts and greater spatial and temporal precision than previously possible.
His recent publications reveal a strong focus on membrane-bound pyrophosphatases, with numerous papers examining their structure, function, and inhibition mechanisms. Other significant research areas include protein structure related to autism spectrum disorder (PTCHD1 research), oncogenic mutations, and host-pathogen interactions. His work demonstrates a consistent pattern of investigating membrane protein structure-function relationships with implications for drug development.
Professor Goldman currently leads several major research projects including 'PTCHD1: towards a molecular and cellular understanding of autism spectrum disorder' (2023-2027, funded by the Research Council of Finland), 'Molecular basis of oncogenic mutations' (2023-2025), and previously led 'Novel inhibitors of protozoan parasites' (2015-2018, funded by the Jane & Aatos Erkko Foundation).
His academic service includes extensive supervision of doctoral students, participation in numerous conferences and workshops worldwide, and membership in various review committees including for the Israel Research Foundation, Norwegian Research Foundation, and EU funding bodies. He has been actively involved in international collaborations through projects like the Marie Curie ITN ViBrANT (2018-2021) and RAMP (2017-2021).
