معرفی
Adeyemi Adedeji serves as Distinguished Scientist-Pathologist and Head of Clinical Pathology in Translational Safety Pathology within Development Sciences at Genentech, where he has contributed for nine years to oncology and non-oncology therapeutic safety assessment. His expertise bridges clinical pathology, translational biomarker development, and immunotoxicology to support preclinical safety evaluation of biologics and small molecules.
His educational background includes:
- Doctor of Veterinary Medicine (DVM) from University of Ibadan, Nigeria (2005)
- PhD in Molecular Microbiology from University of Missouri-Columbia (2012)
- Veterinary Clinical Pathology Residency at University of California-Davis (2015)
- Diplomate of American College of Veterinary Pathologists (2015)
Dr. Adedeji's research focuses on advancing clinical pathology endpoints for drug safety assessment, with particular emphasis on urinary biomarker development, immunotoxicology, and implementation of 3Rs principles (Replacement, Reduction, Refinement) in toxicity studies. His work has established novel approaches for urinary biomarker normalization, microsampling techniques, and fasting protocol optimization to enhance animal welfare without compromising data quality. As Project Pathologist, he integrates clinical pathology data with anatomic findings to assess pharmacological and toxicological effects, directly contributing to regulatory submissions.
His 33 Genentech publications demonstrate consistent focus on translational biomarker qualification, with recent work emphasizing deep learning applications in bone marrow analysis, bispecific antibody safety assessment, and cardiovascular toxicity mechanisms of TGFβ inhibitors. The research shows increasing sophistication in integrating multiple data streams for comprehensive safety assessment.
His scientific recognition includes:
- 3Rs Genentech 1st place Award (2024)
- Society of Toxicology Best Paper Award (2023)
- 3Rs Global Roche 1st place award (2023)
- American College of Toxicology Best Paper Award (2020)
- Multiple Genentech Creative Genius Awards (2017-2018)
As Project Pathologist, Dr. Adedeji provides scientific leadership across multiple therapeutic programs, collaborating with global pathologists and scientists to design preclinical safety studies and interpret findings for regulatory submissions. He actively contributes to establishing scientific standards through participation in the Scientific and Regulatory Policy Committee, focusing on integration of clinical and anatomic pathology data. His work with the 3Rs Advisory Group has led to significant refinements in toxicity study protocols, enhancing animal welfare while maintaining scientific rigor.
Dr. Adedeji leads the Safety Biomarker Expert Resources team, driving scientific and technical support for identification, development, and validation of translational biomarkers. His group collaborates with global biomarker and immunotoxicology teams to advance technologies supporting safety studies and in-vivo safety models.
