معرفی
Abhishek Chatterjee is a Professor of Chemistry at Boston College, where he leads the Chatterjee Group focusing on interdisciplinary protein engineering and genetic code expansion. His work combines directed evolution with chemical approaches to develop novel biotherapeutics, protein conjugates, and tools for probing biological systems. He holds a Ph.D. from Cornell University and has been recognized with prestigious awards including the 2024 Bioconjugate Chemistry Young Investigator Award and 2018 Camille Dreyfus Teacher-Scholar Award.
- Education: Ph.D., Cornell University
His research emphasizes site-directed incorporation of noncanonical amino acids (ncAAs) in mammalian cells to enable bioorthogonal conjugation, gene therapy vectors, and studies of protein post-translational modifications. Innovations include optimized tRNA/synthetase systems and virus-assisted directed evolution platforms. Recent advances include electrochemical protein labeling and quadruplet suppression strategies for multi-ncAA incorporation.
Key contributions include:
- Development of CRACR (Chemoselective Rapid Azo-Coupling Reaction)
- Engineering AAV vectors for targeted gene delivery
- Genetic encoding of protein sulfation in eukaryotes
Awards highlight his impact in bioconjugation and chemical biology. Ongoing work explores scalable biotherapeutic platforms and fundamental protein dynamics using ncAA technologies.
