Jakob von EngelhardtView profile
Professor
Jakob von Engelhardt is a W3 Professor at the Institute of Pathophysiology, University Medical Center of Johannes Gutenberg University Mainz, where he leads a neuroscience research group investigating synaptic communication mechanisms. His team studies how glutamate receptors (AMPA/NMDA) influence neuronal network function, synaptic plasticity, and information processing in the CNS, with implications for neurodegenerative disorders. Research focuses on: Molecular and electrophysiological basis of synaptic transmission Age-related changes in neuronal communication Pathophysiological mechanisms in Alzheimer's, Parkinson's, and Huntington's diseases Roles of auxiliary receptor subunits in synaptic function Publication analysis shows consistent focus on synaptic proteins across 15+ years, with recent work (2014-2018) examining CKAMP44 modulation of AMPA receptors and visual processing. Earlier foundational studies (2008-2010) established contributions of NMDA receptors to spatial learning. The laboratory operates from the Biomedical Research Centre (BFZ) at Johannes Gutenberg University, conducting experimental research using electrophysiological and molecular approaches.