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Dr. Keith Alexander Sharkey is a Professor in the Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He is also a Full Member of both the Hotchkiss Brain Institute and The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases. Dr. Sharkey has been at the University of Calgary since his appointment as Assistant Professor in 1990, dedicating his career to understanding the neural control of the gastrointestinal tract. From 2005-2021, he held the Crohn's and Colitis Canada Chair in Inflammatory Bowel Disease Research, demonstrating his longstanding commitment to advancing knowledge in gastrointestinal sciences. Dr. Sharkey's educational journey began with a BSc (Hons) in Nutrition from the University of London in 1981, followed by a PhD in Physiology from the University of Liverpool in 1985. After completing postdoctoral training in Hungary, the UK, and Canada, he joined the University of Calgary faculty in 1990, where he has remained throughout his distinguished academic career. Dr. Sharkey's research program centers on understanding the physiology and pathophysiology of the neural control of the gastrointestinal tract and brain-gut interactions in health and disease. His laboratory investigates two main areas: the role of the endocannabinoid system in regulating GI motility and intestinal barrier function, and the physiology of the enteric nervous system in controlling motility and barrier function. His work employs state-of-the-art approaches including live cell imaging and molecular genetics. Recent publications show his expanding interest in connections between gut function and neurodegenerative conditions like ALS, with multiple 2024-2025 papers examining sexual dimorphism in disease processes and gut-brain axis mechanisms. Fellow, Royal Society of Canada (2024) Cumming School of Medicine's van de Sande Distinguished Achievement Award for Mentorship (2021) Distinguished Research Award, American Physiological Society (2021) Finkelstein Award for Excellence, Crohn's and Colitis Canada (2016) Fellow, Canadian Academy of Health Sciences (2015) Fellow, Canadian Association of Gastroenterology (2015) Killam Annual Professor Award, University of Calgary (2013) Dr. Sharkey has mentored numerous students throughout his career, as evidenced by his 2021 Mentorship Award. His research is supported by significant funding, including a CIHR Foundation grant exploring how enteric nerves and glia maintain intestinal homeostasis. He has also participated in university strategic initiatives focused on Brain and Mental Health (2015-2021) and Infections, Inflammations and Chronic Diseases (2015-2021), demonstrating his interdisciplinary approach. The Sharkey Lab provides a safe, inclusive, and diverse research environment that encourages open scientific exchange from diverse viewpoints. His laboratory is actively engaged in multiple collaborative projects, including investigations with UBC Okanagan on diet and probiotics targeting the gut-brain metabolic interactome, and with University of Calgary colleagues studying gut microbiota's role in ALS. Dr. Sharkey continues to advance our understanding of neural mechanisms controlling gastrointestinal function with upcoming courses scheduled for Fall 2024 and Winter 2025.

• Enteric nervous system
• Gut-brain axis
• Endocannabinoid system
• +3 more

Professor Chris Holmes is a Professor of Biostatistics at the University of Oxford, where he moved from Imperial College London in February 2004. He is a Fellow at St Anne's College and works in the Department of Statistics. His research focuses on applications and statistical methods development in genomic sciences and genetic epidemiology, holding a prestigious Programme Leaders Grant in Statistical Genomics from the Medical Research Council. Prior to his position at Oxford, Professor Holmes completed his doctorate in Bayesian statistics at Imperial College London, investigating novel nonlinear pattern recognition methods. This was followed by a post-doctoral position and then a lectureship at Imperial. Before his academic career, he worked in industry for several years in scientific computing, developing techniques for real-time pattern recognition models in defense and SCADA systems. Professor Holmes has a broad interest in the theory, methods and applications of statistics and statistical modeling, with a particular foundation in Bayesian statistics which he views as providing a unified framework for stochastic modeling and information processing. His specific research interests include: Bayesian statistics and stochastic simulation Markov chain Monte Carlo methods Pattern recognition and nonlinear, nonparametric methods Spatial statistics Statistical genetics and genomics Genetic epidemiology His recent publications (2023-2025) demonstrate a strong focus on the intersection of biostatistics, artificial intelligence, and healthcare applications. His work spans multiple domains including AI-driven disease classification in neurology, genomic data analysis for health equity, machine learning tools for healthcare prediction, and addressing bias in medical AI systems. A notable trend across his research is the application of advanced statistical methods to solve pressing problems in genomics, epidemiology, and medical diagnostics, with an increasing emphasis on health equity and the ethical implications of AI in healthcare. Professor Holmes currently supervises PhD students Oscar Clivio, Sahra Ghalebikesabi, and Natalia Garcia Martin. His research is supported by multiple grants, including the MRC Programme Leaders Grant in Statistical Genomics which funds his work in statistical genomics. He is actively involved in three research groups at Oxford that reflect the breadth of his scholarly interests: Computational Statistics and Machine Learning Statistical Genetics and Epidemiology Statistical Theory and Methodology

• Bayesian statistics
• Stochastic simulation
• Markov chain Monte Carlo
• +5 more

Thomas Michaels is an Assistant Professor at the Department of Biology, ETH Zürich, leading the Michaels Group . His research focuses on theoretical models of biomolecular condensates and protein aggregation in biological systems. Research Themes : Protein aggregation, liquid-liquid phase separation, membrane biophysics, and the role of condensates in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Collaborative Approach : Integrates theoretical physics, control theory, and computational biology with experimental validation to design therapeutic strategies. Recent Publications highlight his work on amyloid formation mechanisms, lipid interactions, and phase-separated compartments as biochemical reactors. His group trains PhD students in systems biology and biocondensate physics.

• Soft Matter Physics
• Living Matter Physics
• Protein Aggregation
• +5 more

David S. Eisenberg is a Professor of Chemistry and Biochemistry and Biological Chemistry at the University of California, Los Angeles, where he also serves as Director of the UCLA-DOE Institute for Genomics and Proteomics and as an HHMI Investigator. His research focuses on protein interactions, particularly the structural basis for conversion of normal proteins to the amyloid state and conversion of prions to the infectious state. Dr. Eisenberg earned his undergraduate degree in biochemical sciences from Harvard College and his D.Phil. degree in theoretical chemistry from Oxford University on a Rhodes Scholarship. His postdoctoral research was on ice and water with Walter Kauzmann at Princeton and in protein crystallography with Richard Dickerson. He joined the UCLA faculty after his postdoctoral studies. Dr. Eisenberg and his research group focus on protein interactions in amyloid and prion diseases. These diseases involve protein aggregation where normal functional proteins convert to abnormal aggregated forms. Systemic amyloid diseases like dialysis-related amyloidosis result from fiber accumulation until organ failure, while neurodegenerative diseases like Alzheimer's, Parkinson's, ALS, and prion conditions appear to be caused by smaller oligomers. In 2005, his team determined the atomic-level structure for the amyloid fiber spine, revealing a 'steric zipper' of two parallel beta sheets packed across a dry interface. Since then, they've determined approximately 90 amyloid spines from 15 disease-related proteins. In 2010, they identified the structure of a toxic amyloid-related oligomer consisting of six anti-parallel beta strands forming a cylindrical barrel. His recent publications demonstrate continued innovation in amyloid research, with focus areas including structural prediction of amyloid formation, mechanisms of tau fibril disassembly in Alzheimer's disease, cryo-EM analysis of amyloid polymorphism, and structure-based design of inhibitors for amyloid toxicity. His work integrates computational, structural, and biochemical approaches to understand protein aggregation across multiple disease contexts. Dr. Eisenberg has received numerous prestigious awards and honors: National Academy of Sciences Member American Philosophical Society Member Institute of Medicine Member Howard Hughes Medical Institute Investigator Biophysical Society Emily M. Gray Award Harvard Westheimer Medal UCLA Seaborg Medal Technion - Israel Institute of Technology Harvey Prize in Human Health As Director of the UCLA-DOE Institute for Genomics and Proteomics and an HHMI Investigator, Dr. Eisenberg leads significant research initiatives in protein structure and aggregation. His laboratory combines X-ray crystallography, bioinformatics, and biochemical techniques to investigate protein interactions, with particular emphasis on amyloid-forming proteins and their role in disease. The Eisenberg Lab, located in Boyer Hall at UCLA, maintains an active research program investigating the structural basis of protein aggregation. The lab continues to build on its landmark discoveries of amyloid structures while exploring new frontiers in understanding protein misfolding diseases and developing potential therapeutic interventions.

• Protein Aggregation
• Amyloid Structures
• Prion Diseases
• +5 more

Dr. Jiaqi Gong serves as Associate Professor in Computer Science and Adjunct Associate Professor in Mechanical Engineering at The University of Alabama's College of Engineering, while directing the Alabama Center for the Advancement of Artificial Intelligence. His academic foundation includes: B.S. in Engineering, China University of Geoscience (2004) Ph.D. in Engineering, Huazhong University of Science and Technology (2010) Dr. Gong's research pioneers human-AI convergence through cyber-physical systems and smart health technologies, developing mobile/wearable platforms to enhance human perceptual, cognitive, and physical capabilities. His work spans artificial intelligence, machine learning, computer vision, and IoT with applications in healthcare, environmental monitoring, and education. The Sensor-Accelerated Intelligent Learning (SAIL) laboratory he founded drives innovation in behavior change interventions, human movement modeling, and educational data mining. Recent publications reveal strong interdisciplinary trends: healthcare AI dominates with medication adherence prediction and surgical classification systems, while environmental applications feature flood-risk communication and drought analysis. His work increasingly integrates generative AI and LLMs across domains, demonstrating methodological innovation in federated learning, knowledge graphs, and explainable storytelling frameworks. Notable recognitions include: Best Student Paper Award, IEEE/ACM Connected Health Conference (2022) Best Student Paper Award, Body Sensor Networks Conference (2019) Data Challenge Win, IEEE Biomedical Health Informatics (2018) Best Paper Award, Body Area Networks Conference (2014) Best Demonstration Award, IEEE Wireless Health Conference (2014) Dr. Gong leads significant funded projects including a $2M CDC/NIOSH grant for first responder safety and $3M NSF funding for hydrologic research. As SAIL laboratory director, he mentors students in developing clinically deployed technologies for multiple sclerosis, dementia, and mental health. Future work focuses on scaling AI applications in chronic disease management and climate resilience through the Alabama AI Center. The SAIL laboratory (founded 2017) operates as a multidisciplinary hub developing wearable/mobile systems for health applications, with active collaborations across medical clinics and engineering departments for real-world deployment of behavior change interventions and movement analysis tools.

• Artificial Intelligence
• Smart and Connected Health
• Cyber-Physical Systems
• +13 more

Dr. Frank Rudzicz is an Associate Professor in the Faculty of Computer Science at Dalhousie University. His research lies at the intersection of artificial intelligence, natural language processing, and healthcare, with a focus on developing machine learning systems that improve clinical decision-making, patient outcomes, and accessibility in medicine. He holds a BSc from Concordia University (2004), an MEng from McGill University (2006), and a PhD from the University of Toronto (2011). His research interests include Natural Language Processing, Machine Learning, Healthcare, Speech Technologies, Explainable AI, and Fairness in ML. Dr. Rudzicz's recent publications span a wide range of topics, including Alzheimer's detection through speech analysis, surgical outcome prediction, mental health monitoring, privacy in AI, and the application of large language models in clinical settings. His work consistently emphasizes ethical AI, patient privacy, and real-world clinical integration. He has received several awards, including a Best Paper award at EMNLP 2020, a Best Student Paper award at ICASSP 2021, and the ISCA Best Student Paper award in 2013. His research has been published in top-tier journals such as Nature Scientific Reports , JAMA Network Open , IEEE Access , and Frontiers in Human Neuroscience , as well as leading conferences including NeurIPS, ACL, ICML, and Interspeech. Dr. Rudzicz supervises a dynamic research group working on AI for health, with active projects in voice-based diagnostics, ambient clinical documentation, explainable AI for surgery, and wearable-based monitoring for chronic diseases. He collaborates widely across disciplines, including with clinicians, neuroscientists, ethicists, and public health experts. He is also involved in major initiatives such as the Genetics Navigator study and Bridge2AI-Voice, aiming to build ethically sourced, diverse biomedical datasets. His lab actively explores the societal implications of AI in healthcare, including fairness, trust, and resistance to malicious fine-tuning.

• Natural Language Processing
• Machine Learning
• Healthcare
• +12 more

Jessica Williams, PhD is an Assistant Professor in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute (LRI) with additional faculty appointments at Case Western Reserve University, Kent State University, and Cleveland State University. She serves as the Cleveland Clinic liaison for Kent State University and represents the Clinic on the Executive Council for the Brain Health Institute and the Biomedical Sciences Graduate Program Executive Committee. Education: Postdoctoral Fellowship in Neuroimmunology, Washington University School of Medicine (2017) Ph.D. in Immunology, The Ohio State University (2011) M.S. in Physiology, Purdue University (2006) B.S. in Biology/Chemistry, Lindenwood University (2004) Dr. Williams' research focuses on neuroimmune interactions during multiple sclerosis, particularly examining regional responses of CNS glia to immune stimuli and astrocyte-immune crosstalk. Her lab employs murine MS models, primary human and murine cell analyses, and MS patient lesion assessment to investigate cytokine-mediated neuroprotection and CNS repair mechanisms. Recent work highlights protective astrocyte functions mediated by traditionally deleterious cytokines. Analysis of her 15 most recent publications reveals consistent focus on neuroimmune crosstalk in MS, with increasing emphasis on astrocyte heterogeneity, cytokine signaling (particularly IFNγ), and novel therapeutic targets like immunoproteasomes. Key themes include regional CNS differences in immune responses, glial cell repair mechanisms, and translating basic findings into potential MS therapies. Scientific Awards: Lerner Research Institute Excellence in Education Award (2022) Mentor of the Year Award (2023) Dr. Williams actively mentors the next generation of scientists as evidenced by her CIMER Trained Mentor certification and the graduation of PhD student Brandon Smith. Her research is supported by significant funding from the NIH, National MS Society, W.M. Keck Foundation, Brain Health Research Institute, and Neurological and Vision Impact Area. She regularly serves on study sections for the NIH, National MS Society, and Department of Defense. The Williams Laboratory investigates the interplay between immune and central nervous systems during MS, with current projects examining cytokine-mediated neuroimmune crosstalk for CNS repair and regionally distinct glial responses to inflammation. The lab employs advanced techniques including murine MS models and primary human cell analyses to identify novel therapeutic pathways for MS patients.

• Neuroimmunology
• Multiple Sclerosis
• Astrocyte Biology
• +5 more

Masato Kato serves as Professor in the Department of Biochemistry at the University of Texas Southwestern Medical Center since 2020 and concurrently as Team Leader at Japan's National Institutes for Quantum and Radiological Science and Technology. His academic trajectory includes progressive appointments from Assistant Professor (2004-2014) to Associate Professor (2014-2020) at UT Southwestern, with prior postdoctoral training at Harvard Medical School and Nara Institute of Science and Technology. 2020-present: Professor, Department of Biochemistry, UT Southwestern 2020-present: Team Leader, National Institutes for Quantum and Radiological Science and Technology, Japan 2014-2020: Associate Professor, Department of Biochemistry, UT Southwestern 2010-2014: Assistant Professor, Department of Biochemistry and Internal Medicine, UT Southwestern 2004-2010: Assistant Professor, Department of Internal Medicine, UT Southwestern 1999-2004: Postdoctoral Fellow, Ellenberger Lab, Harvard Medical School 1998-1999: Postdoctoral Fellow, Hakoshima Lab, Nara Institute of Science and Technology Dr. Kato's research pioneers the biophysical characterization of protein phase separation, particularly focusing on low-complexity domains (LCDs) in neurodegenerative disease contexts. His work establishes fundamental mechanisms of biomolecular condensate formation, including hydrogel polymerization, liquid-solid transitions, and mutation-induced dysregulation in ALS/FTD. Key contributions demonstrate how C9orf72-encoded poly-dipeptides disrupt nucleocytoplasmic transport and how redox states regulate Ataxin-2 phase behavior, bridging structural biochemistry with pathological mechanisms. Analysis of his 22 publications reveals a cohesive research program centered on LCD-driven phase transitions. The most recent 15 articles (2012-2019) systematically investigate pathological aggregation in neurodegeneration, structural basis of condensate formation, and regulatory mechanisms like phosphorylation and oxidation. This body of work establishes LCDs as central players in both physiological RNA granule assembly and disease-associated solidification, with strong emphasis on C9orf72-related ALS/FTD mechanisms. Dr. Kato maintains active leadership within the McKnight Laboratory at UT Southwestern, where his team employs integrated approaches spanning structural biology, cell biology, and biophysics to dissect phase separation mechanisms. His collaborative network includes prominent neuroscience and biochemistry groups, with co-authorship on key studies in Cell, Science, and PNAS.

• Protein Phase Separation
• Low-Complexity Domains
• RNA Granule Biogenesis
• +3 more

Aditi Das is a Full Professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology, College of Sciences. She leads the Das Laboratory, which focuses on the biochemistry and chemical biology of lipids, particularly studying cytochrome P450 enzymes and their role in lipid metabolism, endocannabinoid systems, and inflammatory pathways. Her educational background includes: B.Sc. in Chemistry from St. Stephen's College M.Sc. in Chemistry from Indian Institute of Technology, Kanpur (I.I.T) Ph.D. in Chemistry from Princeton University Postdoctoral research at Northwestern University (NSF-NSEC fellow) and Beckman Institute for Advanced Science and Technology, University of Illinois UC Professor Das's research interests center around understanding the physiological role of lipids in sustaining homeostasis and their implications in disease states such as neurodegenerative disorders, cancer, and cardiovascular diseases. Her laboratory specializes in: Enzymology of cytochrome P450s, particularly CYP2J2 epoxygenase Metabolism of ω-3 and ω-6 fatty acids and their derivatives Minor cannabinoid metabolism by cytochrome P450 enzymes Discovery of novel anti-inflammatory lipid metabolites and endocannabinoids Mechanistic studies of membrane proteins using nanodisc technology Her work bridges biochemistry, chemical biology, and pharmacology to uncover novel therapeutic targets related to lipid signaling pathways. Analysis of Professor Das's recent publications (2023-2025) reveals a strong focus on cannabinoid metabolism by cytochrome P450 enzymes, with particular emphasis on how these metabolic processes generate bioactive compounds that interact with the endocannabinoid system. Her research increasingly explores the therapeutic potential of omega-3 derived endocannabinoid epoxides in inflammatory and neurodegenerative conditions. The use of nanodisc technology for studying membrane proteins in near-native environments remains a consistent methodological thread throughout her work, enabling detailed mechanistic insights into enzyme function. Professor Das has received numerous prestigious awards recognizing her research excellence and teaching: 2024 NIH Outstanding Researcher Award (MIRA R35) for established investigators 2024 Vasser Woolley Faculty Fellowship 2023 Plenary Lecture at the International Society of the Study of Xenobiotics (ISSX) 2021 E.L.R. Stokstad Award 2019-2021 List of Teachers Ranked as Excellent 2019 Eicosanoid Research Foundation Young Investigator Award 2019 Zoetis Research Excellence Award 2019 Mary Swartz Rose Young Investigator Award 2015 National Scientist Development Award from the American Heart Association 2022 El Sohly Award from the American Chemical Society Professor Das actively mentors a diverse group of students and postdoctoral researchers, with several former lab members now holding faculty positions or working at prestigious institutions. Her laboratory has secured significant funding from NIH, NSF, and other sources to support research on lipid metabolism, cannabinoid pharmacology, and membrane protein biochemistry. Notable grants include an NIH R35 Outstanding Investigator Award (MIRA), an NIH R21 grant from NIDA, and multiple collaborative grants with other research groups. The Das Laboratory operates within the Petit Institute of Bioengineering and Biosciences (IBB) at Georgia Tech, utilizing state-of-the-art facilities for biochemical and biophysical studies. The lab specializes in nanodisc technology to study membrane proteins in near-native environments, with particular expertise in cytochrome P450 enzymes and their interactions with lipid substrates. Recent work has expanded into collaborative projects involving lipidomics, structural biology, and translational applications of lipid signaling research.

• Biochemistry and Chemical biology of Lipids
• Mechanism of Membrane proteins in Nanodiscs
• Enzymology of metalloproteins
• +5 more

Ahmed Hassoon is an Assistant Research Professor at the Johns Hopkins Bloomberg School of Public Health, with a primary appointment in the Department of Epidemiology and joint appointments in the Department of Neurology at the School of Medicine and the School of Engineering. He is affiliated with several key research centers, including the Welch Center for Prevention, Epidemiology and Clinical Research, the Center for Diagnostic Excellence, and the Center for Humanitarian Health. MPH, Johns Hopkins Bloomberg School of Public Health, 2014 MD, Baghdad College of Medicine, 2004 Dr. Hassoon’s research is centered on leveraging data science and artificial intelligence to improve healthcare quality and safety, particularly in diagnostic accuracy. His work spans applications in lung cancer, stroke, and emergency medicine, with a strong emphasis on reducing diagnostic errors using frameworks like symptom-disease pair analysis (SPADE). He is deeply engaged in developing AI models that reason across multiple clinical modalities to enhance patient outcomes. His recent publications highlight a strong trend in diagnostic safety, AI-driven interventions, and epidemiological analysis of misdiagnosis harms. Key themes include the validation of computable phenotypes, measurement of diagnostic error burden, and the impact of mental health on acute care diagnostics. Hubert Humphrey Fellowship Award, U.S. Department of State (2010) US President Appreciation Certificate, The White House (2011) Atlas Corps Award (2012) Sommer Scholarship Award (2013) State of Maryland Cigarette Restitution Fund Faculty and Translational Research Awards (2016–2017) Institute for Healthcare Improvement (IHI) Fellowship (2024) Dr. Hassoon is a recipient of the AHRQ K08 Career Development Award focused on improving cancer diagnostic safety at Johns Hopkins Hospital. He co-instructs graduate-level courses in data science and AI with Professor Brian Caffo, contributing to the training of the next generation of public health data scientists. He has not formally advised students listed in the provided texts. His collaborative research spans multiple institutions and has been widely disseminated through policy, news, and social media, indicating significant real-world impact. His work is deeply integrated with the Welch Center and the Center for Diagnostic Excellence, where he contributes to translational research initiatives aimed at improving clinical decision-making and patient safety through innovative data-driven approaches.

• Artificial Intelligence
• Multi-modal reasoning
• Diagnostic Safety
• +9 more

Nick Bansback is an Honorary Visiting Professor in the School of Population and Public Health at the University of British Columbia (primary affiliation) and affiliated with NUS Saw Swee Hock School of Public Health. His research focuses on maximizing healthcare value through economic evaluation, patient preference measurement, and decision analysis. He holds a PhD in Health Economics and Decision Sciences (University of Sheffield, 2010), an MSc in Health Economics (2004), and a BSc in Mathematics (2001). Key research areas include health technology assessment, patient-reported outcomes, and cost-effectiveness analysis of treatments for chronic conditions like rheumatoid arthritis and multiple sclerosis. He has pioneered methods for incorporating patient preferences into healthcare decisions, including developing decision aids and discrete-choice experiments. His work has been recognized with awards such as the UBC Killam Research Award (2020) and the Canadian Agency for Drugs and Technology in Health Rising Star Award (2016). He has contributed to over 30 peer-reviewed publications, emphasizing practical applications of health economics to improve healthcare resource allocation and patient-centered care. Prof. Bansback’s career spans postdoctoral research at UBC, health economics roles at the Centre for Health Evaluation and Outcomes Sciences, and early research at the University of Sheffield. His interdisciplinary approach bridges clinical practice, policy, and quantitative methods to address complex healthcare challenges.

• Health Economics
• Decision Analysis
• Health Technology Assessment
• +5 more

Jonathan Santo is a Professor of Psychology at the University of Nebraska at Omaha (UNO), where he serves as Director of the Graduate Developmental Psychology Program and as a faculty member in the Office of Latino/Latin-American Studies. His research explores peer relations, cultural differences in self-esteem, and classroom-level influences on child and adolescent development, with a focus on improving school environments and fostering positive social interactions. ORCA Faculty Fellow His research spans broad areas including Developmental Psychology , Social Support Systems , and Cross-Cultural Peer Dynamics , with specific attention to peer victimization , self-continuity , school climate , and developmental trajectories in Brazilian and Colombian youth . Recent publications analyze topics like hikikomori experiences , friendship security , and HPA axis dysregulation in adolescents. Scientific awards include the ORCA Faculty Fellow recognition. His work often involves longitudinal assessments of peer relationships cross-cultural comparisons (Brazil, Colombia, China, Nigeria, Singapore, U.S.) policy-focused blog posts on family separations and school interventions

• Developmental Psychology
• Peer Relations
• Child and Adolescent Development
• +3 more

Christopher Buckley is the Kennedy Professor of Translational Rheumatology and Director of Clinical Research at the Kennedy Institute of Rheumatology, University of Oxford. He holds concurrent roles as Director of NIHR Infrastructure for Birmingham Health Partners. His research focuses on fibroblast biology in rheumatoid arthritis (RA), stromal cell interactions, and translational medicine approaches to stratified therapy. He leads the Arthritis Therapy Acceleration Programme (A-TAP), advancing precision medicine strategies for immune-mediated inflammatory diseases. Educations: BSc Biochemistry, University of Oxford (1985) MBBS Medicine, Royal Free Hospital, London (1990) DPhil in Molecular Medicine (Wellcome Trust Fellowship) under Prof. John Bell (Oxford) Research Interests: Pathogenic fibroblast subpopulations in RA and systemic sclerosis Tissue-resident memory T cells in chronic inflammation Spatial transcriptomics of synovial and tendon tissues Pro-resolving fibroblast networks during inflammation resolution Development of biomarkers for disease flare/remission Awards & Leadership: MRC Senior Clinical Fellowship (2001) Arthritis Research UK Professorship (2002) Director, Birmingham NIHR Clinical Research Facility (2012-2017) Key Projects: Leading A-TAP's stratified pathology approach for drug development Investigating Wnt signaling in stromal inflammation Developing cellular atlases of joints using spatial transcriptomics

• Rheumatology
• Inflammatory Diseases
• Fibroblast Biology
• +3 more

Montserrat Anguera, Ph.D. is an Associate Professor in the Department of Biomedical Sciences at the University of Pennsylvania's School of Veterinary Medicine. Her research focuses on epigenetic mechanisms of gene regulation underlying sex differences in development and disease, with particular emphasis on X-chromosome inactivation (XCI) and its implications for female-biased autoimmune disorders. Dr. Anguera investigates how gene expression from the X-chromosome is regulated to ensure dosage compensation between males and females, and how these mechanisms become altered in diseases exhibiting sex-bias. Her laboratory has established novel epigenetic pathways involving the X-chromosome that impact human development, immune responses, and lymphocyte function. She employs advanced techniques including RNA/DNA fluorescence in situ hybridization, immunofluorescence, and allele-specific RNA sequencing to achieve single-cell resolution of epigenetic characteristics of the inactive X chromosome. Her research reveals a consistent focus on the intersection of X-chromosome biology and immunology, particularly regarding sex-biased autoimmune diseases like systemic lupus erythematosus. Key findings include the discovery that lymphocytes maintain X-chromosome inactivation differently than other somatic cells, with the inactive X exhibiting euchromatic features in female lymphocytes that may underlie female bias in autoimmune disorders. She coined the term 'dynamic XCI maintenance' to describe how T and B cells relocalize Xist RNA and heterochromatic marks to the inactive X chromosome following antigen-mediated stimulation. Dr. Anguera's laboratory includes postdocs Katherine Forsyth and Nikhil Jiwrajka, research specialist Zowie Searcy, graduate students Isabel Sierra and Natalie Toothacre, postdoctoral researcher Nuriban Valero-Pacheco, and PhD student Emma Welter. Together, they investigate epigenetic regulation of X-linked genes in development and disease contexts. She is an active member of multiple prestigious research institutes at Penn, including the Epigenetics Institute, Institute for Immunology, Center for Research on Reproduction & Women's Health, and Institute for Regenerative Medicine. Her work bridges epigenetics, immunology, and developmental biology, providing novel insights into mechanisms underlying female-biased autoimmune disorders.

• Epigenetics
• X-Chromosome Inactivation
• Long Noncoding RNAs
• +6 more

Maria T. Schultheis is a Professor in Drexel University's Department of Psychological and Brain Sciences and holds a joint appointment in the School of Biomedical Engineering, Science and Health Systems. As Interim Director of Clinical Training, she oversees clinical psychology education. She earned her PhD in Clinical Psychology from Drexel University in 1998. Her research focuses on neurorehabilitation, particularly applying virtual reality (VR) technology to assess and improve driving capacity and everyday functioning in individuals with neurological disorders like traumatic brain injury, stroke, and multiple sclerosis. She has pioneered VR-based driving simulators for clinical evaluation and rehabilitation. Her work integrates clinical psychology, engineering, and transportation science, addressing cognitive, physical, and behavioral demands of driving post-neurological injury. Key projects include developing driving assessment protocols for disabled populations and investigating fatigue management in MS patients. Her interdisciplinary approach has been funded by NIH, NIDRR, and the NMSS. Notable awards include the 2007 APA Early Career Award (Division 40) and recognition from the National Academy of Neuropsychology. Schultheis leads the Applied Neuro-Technologies Lab, emphasizing ecologically valid methodologies. Over 35 peer-reviewed publications and presentations at international forums highlight her contributions. She serves on the National Research Council’s Transportation Research Board, influencing policy on neurological disorders and mobility. Grants have supported projects like VR-based financial competency assessments and understanding dual-task demands in post-concussion driving. Her research also explores decision-making competency in young adults and the neurocognitive correlates of risky driving behaviors. Collaborations with biomedical engineers and transportation specialists reflect her commitment to bridging clinical practice and technological innovation for functional recovery.

• Neurorehabilitation
• Virtual Reality Technology in Psychology
• Driving Capacity After Neurological Compromise
• +3 more